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Translating daily COVID-19 screening into a simple glucose test: a proof of concept study.
Liu, Ran; Hu, Yuansheng; He, Ying; Lan, Tian; Zhang, Jingjing.
  • Liu R; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University Nanjing 210023 China jing15209791@nju.edu.cn.
  • Hu Y; The Third Affiliated Hospital of Anhui Medical University, Binhu Hospital of Hefei City Hefei 230022 China.
  • He Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University Nanjing 210023 China jing15209791@nju.edu.cn.
  • Lan T; GlucoSentient, Inc. 2100 S. Oak Street, Suite 101 Champaign IL 61820 USA.
  • Zhang J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University Nanjing 210023 China jing15209791@nju.edu.cn.
Chem Sci ; 12(26): 9022-9030, 2021 Jul 07.
Article in English | MEDLINE | ID: covidwho-1262016
ABSTRACT
Home testing is an attractive emerging strategy to combat the COVID-19 pandemic and prevent overloading of healthcare resources through at-home isolation, screening and monitoring of symptoms. However, current diagnostic technologies of SARS-CoV-2 still suffer from some drawbacks because of the tradeoffs between sensitivity, usability and costs, making the test unaffordable to most users at home. To address these limitations, taking advantage of clustered regularly interspaced short palindromic repeats (CRISPRs) and a portable glucose meter (PGM), we present a proof-of-concept demonstration of a target-responsive CRISPR-PGM system for translating SARS-CoV-2 detection into a glucose test. Using this system, a specific N gene, N protein, and pseudo-viruses of SARS-CoV-2 have been detected quantitatively with a PGM. Given the facile integration of various bioreceptors into the CRISPR-PGM system, the proposed method provides a starting point to provide patients with a single-device solution that can quantitatively monitor multiple COVID-19 biomarkers at home.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Journal: Chem Sci Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Journal: Chem Sci Year: 2021 Document Type: Article