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Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19).
Anderson, Elizabeth M; Diorio, Caroline; Goodwin, Eileen C; McNerney, Kevin O; Weirick, Madison E; Gouma, Sigrid; Bolton, Marcus J; Arevalo, Claudia P; Chase, Julie; Hicks, Philip; Manzoni, Tomaz B; Baxter, Amy E; Andrea, Kurt P; Burudpakdee, Chakkapong; Lee, Jessica H; Vella, Laura A; Henrickson, Sarah E; Harris, Rebecca M; Wherry, E John; Bates, Paul; Bassiri, Hamid; Behrens, Edward M; Teachey, David T; Hensley, Scott E.
  • Anderson EM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Diorio C; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Goodwin EC; Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • McNerney KO; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Weirick ME; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Gouma S; Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bolton MJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Arevalo CP; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Chase J; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Hicks P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Manzoni TB; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Baxter AE; Department of Pediatrics, Division of Rheumatology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Andrea KP; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Burudpakdee C; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Lee JH; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Vella LA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Henrickson SE; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Harris RM; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bates P; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bassiri H; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Behrens EM; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Teachey DT; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Hensley SE; Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Pediatric Infect Dis Soc ; 10(5): 669-673, 2021 May 28.
Article in English | MEDLINE | ID: covidwho-1262143
ABSTRACT
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / Spike Glycoprotein, Coronavirus / COVID-19 / Antibodies, Viral / Antibody Formation Type of study: Prognostic study Limits: Child / Female / Humans / Male Language: English Journal: J Pediatric Infect Dis Soc Year: 2021 Document Type: Article Affiliation country: Jpids

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / Spike Glycoprotein, Coronavirus / COVID-19 / Antibodies, Viral / Antibody Formation Type of study: Prognostic study Limits: Child / Female / Humans / Male Language: English Journal: J Pediatric Infect Dis Soc Year: 2021 Document Type: Article Affiliation country: Jpids