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A Perspective on Personalized Therapies in Hypertrophic Cardiomyopathy.
Goldspink, Paul H; Warren, Chad M; Kitajewski, Jan; Wolska, Beata M; Solaro, R John.
  • Goldspink PH; Department of Physiology and Biophysics and Center for Cardiovascular Research, Chicago, IL; and.
  • Warren CM; Department of Physiology and Biophysics and Center for Cardiovascular Research, Chicago, IL; and.
  • Kitajewski J; Department of Physiology and Biophysics and Center for Cardiovascular Research, Chicago, IL; and.
  • Wolska BM; Department of Physiology and Biophysics and Center for Cardiovascular Research, Chicago, IL; and.
  • Solaro RJ; Division of Cardiology, Department of Medicine, University of Illinois at Chicago, College of Medicine, Chicago, IL.
J Cardiovasc Pharmacol ; 77(3): 317-322, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-1262260
ABSTRACT
ABSTRACT A dominant mechanism of sudden cardiac death in the young is the progression of maladaptive responses to genes encoding proteins linked to hypertrophic cardiomyopathy. Most are mutant sarcomere proteins that trigger the progression by imposing a biophysical defect on the dynamics and levels of myofilament tension generation. We discuss approaches for personalized treatments that are indicated by recent advanced understanding of the progression.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Death, Sudden, Cardiac / Precision Medicine Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Cardiovasc Pharmacol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Death, Sudden, Cardiac / Precision Medicine Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Cardiovasc Pharmacol Year: 2021 Document Type: Article