Your browser doesn't support javascript.
Risk factors for seasonal human coronavirus lower respiratory tract infection after hematopoietic cell transplantation.
Ogimi, Chikara; Xie, Hu; Waghmare, Alpana; Ueda Oshima, Masumi; Mallhi, Kanwaldeep K; Jerome, Keith R; Leisenring, Wendy M; Englund, Janet A; Boeckh, Michael.
  • Ogimi C; Pediatric Infectious Diseases Division, Seattle Children's Hospital, Seattle, WA.
  • Xie H; Department of Pediatrics, University of Washington, Seattle, WA.
  • Waghmare A; Vaccine and Infectious Disease Division and.
  • Ueda Oshima M; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Mallhi KK; Pediatric Infectious Diseases Division, Seattle Children's Hospital, Seattle, WA.
  • Jerome KR; Department of Pediatrics, University of Washington, Seattle, WA.
  • Leisenring WM; Vaccine and Infectious Disease Division and.
  • Englund JA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Boeckh M; Division of Medical Oncology.
Blood Adv ; 5(7): 1903-1914, 2021 04 13.
Article in English | MEDLINE | ID: covidwho-1263006
ABSTRACT
Data are limited regarding risk factors for lower respiratory tract infection (LRTI) caused by seasonal human coronaviruses (HCoVs) and the significance of virologic documentation by bronchoalveolar lavage (BAL) on outcomes in hematopoietic cell transplant (HCT) recipients. We retrospectively analyzed patients undergoing allogeneic HCT (4/2008-9/2018) with HCoV (OC43/NL63/HKU1/229E) detected by polymerase chain reaction during conditioning or post-HCT. Risk factors for all manifestations of LRTI and progression to LRTI among those presenting with HCoV upper respiratory tract infection (URTI) were analyzed by logistic regression and Cox proportional hazard models, respectively. Mortality rates following HCoV LRTI were compared according to virologic documentation by BAL. A total of 297 patients (61 children and 236 adults) developed HCoV infection as follows 254 had URTI alone, 18 presented with LRTI, and 25 progressed from URTI to LRTI (median, 16 days; range, 2-62 days). Multivariable logistic regression analyses showed that male sex, higher immunodeficiency scoring index, albumin <3 g/dL, glucose >150 mg/dL, and presence of respiratory copathogens were associated with occurrence of LRTI. Hyperglycemia with steroid use was associated with progression to LRTI (P < .01) in Cox models. LRTI with HCoV detected in BAL was associated with higher mortality than LRTI without documented detection in BAL (P < .01). In conclusion, we identified factors associated with HCoV LRTI, some of which are less commonly appreciated to be risk factors for LRTI with other respiratory viruses in HCT recipients. The association of hyperglycemia with LRTI might provide an intervention opportunity to reduce the risk of LRTI.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Coronavirus Infections / Hematopoietic Stem Cell Transplantation Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Infant, Newborn Country/Region as subject: North America Language: English Journal: Blood Adv Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Coronavirus Infections / Hematopoietic Stem Cell Transplantation Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Infant, Newborn Country/Region as subject: North America Language: English Journal: Blood Adv Year: 2021 Document Type: Article