Antibody response to inactivated COVID-19 vaccine (CoronaVac) in immune-mediated diseases: a controlled study among hospital workers and elderly.
Rheumatol Int
; 41(8): 1429-1440, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1263142
ABSTRACT
OBJECTIVE:
To assess antibody response to inactivated COVID-19 vaccine in patients with immune-mediated diseases (IMD) among hospital workers and people aged 65 and older.METHODS:
In this cross-sectional study, we studied 82 hospital workers with IMD (mean age 42.2 ± 10.0 years) and 300 (mean age 41.7 ± 9.9 years) controls. Among + 65 aged population, we studied 22 (mean age 71.4 ± 4.5 years) patients and 47 controls (mean age 70.9 ± 4.8 years). All study subjects had a negative history for COVID-19. Sera were obtained after at least 21 days following the second vaccination. Anti-spike IgG antibody titers were measured quantitatively using a commercially available immunoassay method.RESULTS:
Patients with IMD were significantly less likely to have detectable antibodies than healthy controls both among the hospital workers (92.7% vs 99.7%, p < 0.001) and elderly population (77.3% vs 97.9%, p = 0.011). Among patients with IMD, those using immunosuppressive or immune-modulating drugs (64/75, 85.3%) were significantly less likely to have detectable antibodies compared to those off treatment (29/29, 100%) (p = 0.029). Additionally, a negative association between age and the antibody titer categories among patients (r = - 0.352; p < 0.001) and controls (r = - 0.258; p < 0.001) were demonstrated.CONCLUSIONS:
Among hospital workers, the vast majority of patients with IMD and immunocompetent controls developed a significant humoral response following the administration of the second dose of inactivated COVID-19 vaccine. This was also true for the elderly population, albeit with lower antibody titers. Immunosuppressive use, particularly rituximab significantly reduced antibody titers. Antibody titers were significantly lower among those aged ≥ 60 years both in patient and control populations. Whether these individuals should get a booster dose warrants further studies.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Personnel, Hospital
/
Immunoglobulin G
/
Mass Vaccination
/
Immunity, Humoral
/
Immunogenicity, Vaccine
/
COVID-19 Vaccines
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Immune System Diseases
/
Antibodies, Viral
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
/
Variants
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
Asia
Language:
English
Journal:
Rheumatol Int
Year:
2021
Document Type:
Article
Affiliation country:
S00296-021-04910-7
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