Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation.
Mol Cell Biochem
; 476(10): 3815-3825, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1263168
ABSTRACT
Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombosis
/
Chagas Disease
/
COVID-19
/
Heparitin Sulfate
/
Anticoagulants
Type of study:
Etiology study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Mol Cell Biochem
Year:
2021
Document Type:
Article
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