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Combining subsidiary and synchronous approaches for concurrent spectrofluorimetric assurance of lopinavir and ritonavir in tablets utilized in convention for treatment of coronavirus infection (COVID-19) and biological fluids.
Salem, Hesham; Samir, Ebtihal; Abdelaziz, Amany; Alaa El-Din, Mahmoud; Abdelgaleel, Mahmoud; Zein, Dina; Madian, Hoda.
  • Salem H; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt. Electronic address: hesham.salem@deraya.edu.eg.
  • Samir E; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
  • Abdelaziz A; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
  • Alaa El-Din M; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
  • Abdelgaleel M; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
  • Zein D; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
  • Madian H; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc ; 262: 120066, 2021 Dec 05.
Article in English | MEDLINE | ID: covidwho-1263373
ABSTRACT
In this think about, assurance of lopinavir and ritonavir down to organic concentration level has been carried out. The assurance is based on expanding the selectivity of the spectrofluorimetric procedure by combining both subordinate and synchronous spectrofluorimetric approaches, which allow effective estimation of lopinavir at 248.8 nm and ritonavir at 300.1 nm within the nearness of each other at Δλ of 60 nm. Worldwide Conference on Harmonization approval rules were taken after to completely approve the strategy, and linearity was gotten for the two drugs over the extend of 0.4-2.4 µg mL-1 for Lopinavir and 0.1-0.6 µg mL-1 for ritonavir. Application of of the strategy was successfully carried out within the commercial tablets with great understanding with the comparison strategies. As the detection limits were down to 0.133 and 0.022 µg mL-1 and quantitation limits were 0.395 and 0.068 µg mL-1 for lopinavir and ritonavir, individually; the in vivo assurance of lopinavir and ritonavir in spiked plasma tests was pertinent. The rate recuperations in natural tests were 99.10 ± 0.77 and 99.54 ± 0.60 for lopinavir and ritonavir, individually. Water was utilized as the ideal weakening dissolvable within the proposed strategy which includes an eco-friendly justify.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / COVID-19 Limits: Humans Language: English Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: Molecular Biology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / COVID-19 Limits: Humans Language: English Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: Molecular Biology Year: 2021 Document Type: Article