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Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device.
Zhang, Yuwei; Malekjahani, Ayden; Udugama, Buddhisha N; Kadhiresan, Pranav; Chen, Hongmin; Osborne, Matthew; Franz, Max; Kucera, Mike; Plenderleith, Simon; Yip, Lily; Bader, Gary D; Tran, Vanessa; Gubbay, Jonathan B; McGeer, Allison; Mubareka, Samira; Chan, Warren C W.
  • Zhang Y; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
  • Malekjahani A; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Udugama BN; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Kadhiresan P; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Chen H; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Osborne M; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Franz M; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Kucera M; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Plenderleith S; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Yip L; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Bader GD; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Tran V; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Gubbay JB; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • McGeer A; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Mubareka S; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
  • Chan WCW; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
Nano Lett ; 21(12): 5209-5216, 2021 06 23.
Article in English | MEDLINE | ID: covidwho-1263457
ABSTRACT
The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. The lateral flow assay misdiagnosed ∼2 out of 3 SARS-CoV-2 positive patients. Our quantum dot barcode device has ∼3 times greater clinical sensitivity because it is ∼140 times more analytically sensitive than lateral flow assays. Our device can diagnose SARS-CoV-2 at different sampling dates and infectious severity. We developed a databasing app to provide instantaneous results to inform patients, physicians, and public health agencies. This assay and device enable real-time surveillance of SARS-CoV-2 seroprevalence and potential immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quantum Dots / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Nano Lett Year: 2021 Document Type: Article Affiliation country: Acs.nanolett.1c01280

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quantum Dots / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Nano Lett Year: 2021 Document Type: Article Affiliation country: Acs.nanolett.1c01280