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Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device.
Zhang, Yuwei; Malekjahani, Ayden; Udugama, Buddhisha N; Kadhiresan, Pranav; Chen, Hongmin; Osborne, Matthew; Franz, Max; Kucera, Mike; Plenderleith, Simon; Yip, Lily; Bader, Gary D; Tran, Vanessa; Gubbay, Jonathan B; McGeer, Allison; Mubareka, Samira; Chan, Warren C W.
  • Zhang Y; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
  • Malekjahani A; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Udugama BN; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Kadhiresan P; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Chen H; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Osborne M; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Franz M; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Kucera M; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Plenderleith S; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Yip L; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Bader GD; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Tran V; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Gubbay JB; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • McGeer A; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  • Mubareka S; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
  • Chan WCW; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
Nano Lett ; 21(12): 5209-5216, 2021 06 23.
Article in English | MEDLINE | ID: covidwho-1263457
Semantic information from SemMedBD (by NLM)
1. portable biomedical equipment USES Smartphone
Subject
portable biomedical equipment
Predicate
USES
Object
Smartphone
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Patients USES portable biomedical equipment
Subject
Patients
Predicate
USES
Object
portable biomedical equipment
4. Medical Devices DIAGNOSES 2019 novel coronavirus
Subject
Medical Devices
Predicate
DIAGNOSES
Object
2019 novel coronavirus
5. portable biomedical equipment USES Smartphone
Subject
portable biomedical equipment
Predicate
USES
Object
Smartphone
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Patients USES portable biomedical equipment
Subject
Patients
Predicate
USES
Object
portable biomedical equipment
8. Medical Devices DIAGNOSES 2019 novel coronavirus
Subject
Medical Devices
Predicate
DIAGNOSES
Object
2019 novel coronavirus
ABSTRACT
The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. The lateral flow assay misdiagnosed ∼2 out of 3 SARS-CoV-2 positive patients. Our quantum dot barcode device has ∼3 times greater clinical sensitivity because it is ∼140 times more analytically sensitive than lateral flow assays. Our device can diagnose SARS-CoV-2 at different sampling dates and infectious severity. We developed a databasing app to provide instantaneous results to inform patients, physicians, and public health agencies. This assay and device enable real-time surveillance of SARS-CoV-2 seroprevalence and potential immunity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Quantum Dots / COVID-19 Subject: Quantum Dots / COVID-19 Type of study: Diagnostic study Language: English Journal: Nano Lett Clinical aspect: Diagnosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Quantum Dots / COVID-19 Subject: Quantum Dots / COVID-19 Type of study: Diagnostic study Language: English Journal: Nano Lett Clinical aspect: Diagnosis Year: 2021
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