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Differences in Cardiac Magnetic Resonance Imaging Markers Between Patients With COVID-19-associated Myocardial Injury and Patients With Clinically Suspected Myocarditis.
Maurus, Stephan; Weckbach, Ludwig T; Marschner, Constantin; Kunz, Wolfgang G; Ricke, Jens; Kazmierczak, Philip M; Bieber, Stephanie; Brado, Johannes; Kraechan, Angelina; Hellmuth, Johannes C; Hausleiter, Joerg; Massberg, Steffen; Grabmaier, Ulrich; Curta, Adrian.
  • Maurus S; Departments of Radiology.
  • Weckbach LT; Medicine I.
  • Marschner C; Departments of Radiology.
  • Kunz WG; Departments of Radiology.
  • Ricke J; Departments of Radiology.
  • Kazmierczak PM; Departments of Radiology.
  • Bieber S; Medicine I.
  • Brado J; Medicine I.
  • Kraechan A; Medicine I.
  • Hellmuth JC; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Germany.
  • Hausleiter J; Medicine I.
  • Massberg S; Medicine I.
  • Grabmaier U; Medicine I.
  • Curta A; Departments of Radiology.
J Thorac Imaging ; 36(5): 279-285, 2021 Sep 01.
Article in English | MEDLINE | ID: covidwho-1263732
Semantic information from SemMedBD (by NLM)
1. Myocarditis PROCESS_OF Patients
Subject
Myocarditis
Predicate
PROCESS_OF
Object
Patients
2. myocardial injury PROCESS_OF Patients
Subject
myocardial injury
Predicate
PROCESS_OF
Object
Patients
3. Heart LOCATION_OF Magnetic Resonance Imaging
Subject
Heart
Predicate
LOCATION_OF
Object
Magnetic Resonance Imaging
4. High Level PROCESS_OF Patients
Subject
High Level
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Abnormal Finding PROCESS_OF Patients
Subject
Abnormal Finding
Predicate
PROCESS_OF
Object
Patients
7. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
8. Cardiac involvement COEXISTS_WITH COVID-19
Subject
Cardiac involvement
Predicate
COEXISTS_WITH
Object
COVID-19
9. Myocarditis PROCESS_OF Patients
Subject
Myocarditis
Predicate
PROCESS_OF
Object
Patients
10. myocardial injury PROCESS_OF Patients
Subject
myocardial injury
Predicate
PROCESS_OF
Object
Patients
11. Heart LOCATION_OF Magnetic Resonance Imaging
Subject
Heart
Predicate
LOCATION_OF
Object
Magnetic Resonance Imaging
12. High Level PROCESS_OF Patients
Subject
High Level
Predicate
PROCESS_OF
Object
Patients
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. Abnormal Finding PROCESS_OF Patients
Subject
Abnormal Finding
Predicate
PROCESS_OF
Object
Patients
15. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
16. Cardiac involvement COEXISTS_WITH COVID-19
Subject
Cardiac involvement
Predicate
COEXISTS_WITH
Object
COVID-19
ABSTRACT

PURPOSE:

Coronavirus 2019 disease (COVID-19) has been shown to affect the myocardium, resulting in a worse clinical outcome. In this registry study, we aimed to identify differences in cardiac magnetic resonance imaging (CMRI) between COVID-19 and all-cause myocarditis. MATERIALS AND

METHODS:

We examined CMRI of patients with COVID-19 and elevated high-sensitivity serum troponin levels performed between March 31st and May 5th and compared them to CMRI of patients without SARS-CoV-2 infection with suspected myocarditis in the same time period. For this purpose, we evaluated Lake-Louise Criteria for myocarditis by determining nonischemic myocardial injury via T1-mapping, extracellular volume, late gadolinium enhancement, and myocardial edema (ME) by T2-mapping and fat-saturated T2w imaging (T2Q).

RESULTS:

A total of 15 of 18 (89%) patients with COVID-19 had abnormal findings. The control group consisted of 18 individuals. There were significantly fewer individuals with COVID-19 who had increased T2 (5 vs. 10; P=0.038) and all-cause ME (7 vs. 15; P=0.015); thus, significantly fewer patients with COVID-19 fulfilled Lake-Louise Criteria (6 vs. 17; P<0.001). In contrast, nonischemic myocardial injury was not significantly different. In the COVID-19 group, indexed end-diastolic volume of the left ventricle showed a significant correlation to the extent of abnormal T1 (R2=0.571; P=0.017) and extracellular volume (R2=0.605; P=0.013) and absolute T1, T2, and T2Q (R2=0.644; P=0.005, R2=0.513; P=0.035 and R2=0.629; P=0.038, respectively); in the control group, only extracellular volume showed a weak correlation (R2=0.490; P=0.046).

CONCLUSIONS:

Cardiac involvement in COVID-19 seems to show less ME than all-cause myocarditis. Abnormal CMRI markers correlated to left ventricle dilation only in the COVID-19 group. Larger comparative studies are needed to verify our findings.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Imaging, Cine / COVID-19 / Myocarditis Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: J Thorac Imaging Journal subject: Diagnostic Imaging Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Imaging, Cine / COVID-19 / Myocarditis Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: J Thorac Imaging Journal subject: Diagnostic Imaging Year: 2021 Document Type: Article