Your browser doesn't support javascript.
Impact of immunomodulatory drugs on infectious complications in COVID-19 patients on extracorporeal membrane oxygenation: Analysis of the ELSO registry
Perfusion ; 36(1 SUPPL):31-32, 2021.
Article in English | EMBASE | ID: covidwho-1264066
ABSTRACT

Objective:

To identify the incidence of infections in those receiving immunomodulatory drugs for COVID- 19 during ECMO and the risk factors for infection.

Methods:

Deidentified data on all patients who had ECMO for COVID-19 till July 2020 were analysed from the ELSO Registry. A comparison cohort of patients who did not acquire superinfections during ECMO was used to identify risk factors for infection. Our primary outcome measure was incidence of infections pre- or on ECMO in patients receiving immunomodulatory drugs. Univariate analysis assessed potential associations between survival and various pre-ECMO/ECMOrelated factors. Variables (p< 0.1) entered a logistic regression model which identified predictors of infections in this cohort.

Results:

Of the 1237 patients who required ECMO for COVID-19 related complications, 911 patients (73.6%) received immunomodulatory drugs. 47% of these patients had superinfections, predominantly with gram negative bacteria (56%). Pre-ECMO factors associated with a higher odds of infection included immunodeficiency and treatment with selective cytokine blockers. ECMO complications (mechanical, renal, pulmonary, infectious and metabolic) increased the odds of infection. (Table 1) Patients who developed an infection preor on ECMO had significantly longer ECMO runs than those who did not (491.1±308.9 hours vs 293.4± 240.6hours, p< 0.001) with no mortality difference (45.7% Vs 43.4%, p = 0.45).

Conclusions:

Of the three quarter of patients who received immunomodulatory drugs for COVID-19 during ECMO, 47% had superinfections. Immunodeficiency and use of selective cytokine blockers were risk factors for infections pre or on ECMO in addition to ECMO related complications.

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: English Journal: Perfusion Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: English Journal: Perfusion Year: 2021 Document Type: Article