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SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States.
Cai, Hugh Y; Cai, Allison.
  • Cai HY; Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada.
  • Cai A; Faculty of Science, University of British Colombia, BC, Canada.
J Vet Diagn Invest ; 33(5): 939-942, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1264089
ABSTRACT
Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink-derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529) and U.S. (173,277) SARS-CoV2 sequences deposited in GISAID from December 2019 to March 12, 2021, and identified 2 dominant novel variants, the N501T-G142D variant and N501T-G142D-F486L variant, in the U.S. mink-derived SARS-CoV2 sequences. These variants were not found in mink from Canada or other countries. The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada. The N501T mutation occurred 2 mo earlier in humans than in mink in the United States, and the novel N501T-G142D and N501T-G142D-F486L variants were found in humans prior to mink. Our results suggest that the novel SARS-CoV2 variants may have evolved during human infection and were then transmitted to mink populations in the United States.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Type of study: Experimental Studies / Observational study Topics: Variants Limits: Animals Country/Region as subject: North America Language: English Journal: J Vet Diagn Invest Journal subject: Veterinary Medicine Year: 2021 Document Type: Article Affiliation country: 10406387211023481

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Type of study: Experimental Studies / Observational study Topics: Variants Limits: Animals Country/Region as subject: North America Language: English Journal: J Vet Diagn Invest Journal subject: Veterinary Medicine Year: 2021 Document Type: Article Affiliation country: 10406387211023481