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SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2.
Fenizia, Claudio; Galbiati, Silvia; Vanetti, Claudia; Vago, Riccardo; Clerici, Mario; Tacchetti, Carlo; Daniele, Tiziana.
  • Fenizia C; Department of Pathophysiology and Transplantation, Milano University Medical School, 20122 Milano, Italy.
  • Galbiati S; Department of Biomedical and Clinical Sciences "L. Sacco", Milano University Medical School, 20157 Milano, Italy.
  • Vanetti C; Complication of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
  • Vago R; Department of Pathophysiology and Transplantation, Milano University Medical School, 20122 Milano, Italy.
  • Clerici M; Department of Biomedical and Clinical Sciences "L. Sacco", Milano University Medical School, 20157 Milano, Italy.
  • Tacchetti C; Urological Research Institute, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
  • Daniele T; Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, 20132 Milano, Italy.
Cells ; 10(6)2021 06 08.
Article in English | MEDLINE | ID: covidwho-1264419
ABSTRACT
In late 2019, the betacoronavirus SARS-CoV-2 was identified as the viral agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. Coronaviruses Spike proteins are responsible for their ability to interact with host membrane receptors and different proteins have been identified as SARS-CoV-2 interactors, among which Angiotensin-converting enzyme 2 (ACE2), and Basigin2/EMMPRIN/CD147 (CD147). CD147 plays an important role in human immunodeficiency virus type 1, hepatitis C virus, hepatitis B virus, Kaposi's sarcoma-associated herpesvirus, and severe acute respiratory syndrome coronavirus infections. In particular, SARS-CoV recognizes the CD147 receptor expressed on the surface of host cells by its nucleocapsid protein binding to cyclophilin A (CyPA), a ligand for CD147. However, the involvement of CD147 in SARS-CoV-2 infection is still debated. Interference with both the function (blocking antibody) and the expression (knock down) of CD147 showed that this receptor partakes in SARS-CoV-2 infection and provided additional clues on the underlying mechanism CD147 binding to CyPA does not play a role; CD147 regulates ACE2 levels and both receptors are affected by virus infection. Altogether, these findings suggest that CD147 is involved in SARS-CoV-2 tropism and represents a possible therapeutic target to challenge COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Basigin / Virus Internalization / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10061434

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Basigin / Virus Internalization / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10061434