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The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern Italy.
Russo, Roberta; Andolfo, Immacolata; Lasorsa, Vito Alessandro; Cantalupo, Sueva; Marra, Roberta; Frisso, Giulia; Abete, Pasquale; Cassese, Gian Marco; Servillo, Giuseppe; Esposito, Gabriella; Gentile, Ivan; Piscopo, Carmelo; Della Monica, Matteo; Fiorentino, Giuseppe; Russo, Giuseppe; Cerino, Pellegrino; Buonerba, Carlo; Pierri, Biancamaria; Zollo, Massimo; Iolascon, Achille; Capasso, Mario.
  • Russo R; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Andolfo I; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Lasorsa VA; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Cantalupo S; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Marra R; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Frisso G; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Abete P; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Cassese GM; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Servillo G; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Esposito G; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Gentile I; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Piscopo C; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Della Monica M; COVID Hospital, P.O.S. Anna e SS. Madonna della Neve di Boscotrecase, Ospedali Riuniti Area Vesuviana, 80042 Boscotrecase, Italy.
  • Fiorentino G; COVID Hospital, P.O.S. Anna e SS. Madonna della Neve di Boscotrecase, Ospedali Riuniti Area Vesuviana, 80042 Boscotrecase, Italy.
  • Russo G; Dipartimento di Neuroscienze e Scienze riproduttive ed odontostomatologiche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Cerino P; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Buonerba C; CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.
  • Pierri B; Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy.
  • Zollo M; Medical and Laboratory Genetics Unit, A.O.R.N. 'Antonio Cardarelli', 80131 Napoli, Italy.
  • Iolascon A; Medical and Laboratory Genetics Unit, A.O.R.N. 'Antonio Cardarelli', 80131 Napoli, Italy.
  • Capasso M; AORN dei Colli Presidio Ospedaliero Cotugno, 80131 Napoli, Italy.
Genes (Basel) ; 12(6)2021 06 08.
Article in English | MEDLINE | ID: covidwho-1264428
ABSTRACT
To identify host genetic determinants involved in humoral immunity and associated with the risk of developing severe COVID-19, we analyzed 500 SARS-CoV-2 positive subjects from Southern Italy. We examined the coding sequences of 10 common variable immunodeficiency-associated genes obtained by the whole-exome sequencing of 121 hospitalized patients. These 10 genes showed significant enrichment in predicted pathogenic point mutations in severe patients compared with the non-severe ones. Moreover, in the TNFRSF13C gene, the minor allele of the p.His159Tyr variant, which is known to increase NF-kB activation and B-cell production, was significantly more frequent in the 38 severe cases compared to both the 83 non-severe patients and the 375 asymptomatic subjects further genotyped. This finding identified a potential genetic risk factor of severe COVID-19 that not only may serve to unravel the mechanisms underlying the disease severity but, also, may contribute to build the rationale for individualized management based on B-cell therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Cell Activation Factor Receptor / COVID-19 Type of study: Observational study / Prognostic study / Risk factors Topics: Variants Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Genes12060881

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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Cell Activation Factor Receptor / COVID-19 Type of study: Observational study / Prognostic study / Risk factors Topics: Variants Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Genes12060881