Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets.
J Clin Med
; 10(5)2021 Feb 24.
Article
in English
| MEDLINE | ID: covidwho-1264474
ABSTRACT
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
/
Qualitative research
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Jcm10050894
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