SARS-CoV-2 serological antibody testing: problems of false detections and the solutions

ABSTRACT

The new type of coronavirus pneumonia poses a huge threat to the world. At present, serum antibody testing has become a key indicator for the diagnosis and epidemic control of the disease. In my country's "New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Version 7)", the new coronavirus antibody test has been clearly established as the clinical diagnosis standard. In the actual clinical work process, the author found that there are false positive or false negative problems in the new coronavirus antibody test, which caused confusion in clinical interpretation. This article focuses on the design and principle of the new coronavirus antibody detection method, analyses the reasons that can cause false positive and false negative results, and points out the solutions, so as to promote a better understanding of the new coronavirus antibody detection, and provide a more comprehensive clinical experience Interpretation of results.