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Infectious agents including COVID-19 and the involvement of blood coagulation and fibrinolysis. A narrative review.
Marongiu, F; Grandone, E; Scano, A; Orrù, G; Marongiu, S; Gerosa, C; Fanni, D; Faa, G; Barcellona, D.
  • Marongiu F; Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy. doris.barcellona@unica.it.
Eur Rev Med Pharmacol Sci ; 25(10): 3886-3897, 2021 May.
Article in English | MEDLINE | ID: covidwho-1264765
Semantic information from SemMedBD (by NLM)
1. Bacteria CAUSES Communicable Diseases
Subject
Bacteria
Predicate
CAUSES
Object
Communicable Diseases
2. Virus CAUSES Communicable Diseases
Subject
Virus
Predicate
CAUSES
Object
Communicable Diseases
3. Fibrinolysis AFFECTS Communicable Diseases
Subject
Fibrinolysis
Predicate
AFFECTS
Object
Communicable Diseases
4. Bacteria CAUSES Communicable Diseases
Subject
Bacteria
Predicate
CAUSES
Object
Communicable Diseases
5. Virus CAUSES Communicable Diseases
Subject
Virus
Predicate
CAUSES
Object
Communicable Diseases
6. Fibrinolysis AFFECTS Communicable Diseases
Subject
Fibrinolysis
Predicate
AFFECTS
Object
Communicable Diseases
ABSTRACT

OBJECTIVE:

Platelets, blood coagulation along with fibrinolysis are greatly involved in the pathophysiology of infectious diseases induced by bacteria, parasites and virus. This phenomenon is not surprising since both the innate immunity and the hemostatic systems are two ancestral mechanisms which closely cooperate favoring host's defense against foreign invaders. However, the excessive response of these systems may be dangerous for the host itself. MATERIALS AND

METHODS:

We searched and retrieved the articles, using the following electronic database MedLine and Embase. We limited our search to articles published in English, but no restrictions in terms of article type, publication year, and geography were adopted.

RESULTS:

The hemostatic phenotype of the infectious diseases is variable depending on the points of attack of the different involved pathogens. Infectious diseases which show a prothrombotic phenotype are bacterial sepsis, SARS-CoV-2 and malaria. However, among the bacterial sepsis, Yersinia Pestis is characterized by a profibrinolytic behavior. On the contrary, the hemorrhagic fevers, due to Dengue and Ebola virus, mainly exploit the activation of fibrinolysis secondary to a huge endothelial damage which can release a large amount of t-PA in the early phase of the diseases.

CONCLUSIONS:

Blood coagulation and fibrinolysis are greatly activated based on the strategy of the different infectious agents which exploit the excess of response of both systems to achieve the greatest possible virulence.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Fibrinolysis / COVID-19 Type of study: Reviews Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Eurrev_202105_25956

Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Fibrinolysis / COVID-19 Type of study: Reviews Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Eurrev_202105_25956