Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy.

Hetta, H F; Muhammad, K; Algammal, A M; Ramadan, H; Abdel-Rahman, M S; Mabrok, M; Koneru, G; Elkady, A A; El-Saber Batiha, G; Waheed, Y; Munawar, N; Farghaly, H S M

Hetta, H F; Muhammad, K; Algammal, A M; Ramadan, H; Abdel-Rahman, M S; Mabrok, M; Koneru, G; Elkady, A A; El-Saber Batiha, G; Waheed, Y; Munawar, N; Farghaly, H S M.

Hetta HF; Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. nmunawar@uaeu.ac.ae.

Eur Rev Med Pharmacol Sci ; 25(10): 3923-3932, 2021 May.

Article in English | MEDLINE | ID: covidwho-1264769

ABSTRACT

ABSTRACT

Angiotensin converting enzyme 2 (ACE2) has potentially conflicting roles in health and disease. COVID-19 coronavirus binds to human cells via ACE2 receptor, which is expressed on almost all body organs. Boosting the ACE2 receptor levels on heart and lung cells may provide more cellular enter to virus thereby worsening the infection. Therefore, among the drug targets, ACE2 is suggested as a vital target of COVID-19 therapy. This hypothesis is based on the protective role of the drugs acting on ACE2. Therefore, this review discusses the impact and challenges of using ACE2 as a target in the current therapy of COVID-19.

Subject(s)

Angiotensin-Converting Enzyme 2/antagonists & inhibitors; Antiviral Agents/chemistry; Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/chemistry; Adenosine Monophosphate/metabolism; Adenosine Monophosphate/therapeutic use; Alanine/analogs & derivatives; Alanine/chemistry; Alanine/metabolism; Alanine/therapeutic use; Angiotensin-Converting Enzyme 2/metabolism; Anti-Inflammatory Agents, Non-Steroidal/chemistry; Anti-Inflammatory Agents, Non-Steroidal/metabolism; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Antiviral Agents/metabolism; Antiviral Agents/therapeutic use; Azithromycin/chemistry; Azithromycin/metabolism; Azithromycin/therapeutic use; COVID-19/virology; Humans; Hydroxychloroquine/chemistry; Hydroxychloroquine/metabolism; Hydroxychloroquine/therapeutic use; SARS-CoV-2/isolation & purification; Vitamin D/chemistry; Vitamin D/metabolism; Vitamin D/therapeutic use; COVID-19 Drug Treatment

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Angiotensin-Converting Enzyme 2 Type of study: Experimental Studies Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Eurrev_202105_25963

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google