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Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides.
Dhanjal, Jaspreet Kaur; Kumar, Vipul; Garg, Sukant; Subramani, Chandru; Agarwal, Shubhra; Wang, Jia; Zhang, Huayue; Kaul, Ashish; Kalra, Rajkumar Singh; Kaul, Sunil C; Vrati, Sudhanshu; Sundar, Durai; Wadhwa, Renu.
  • Dhanjal JK; Indraprastha Institute of Information Technology Delhi, Okhla Industrial Estate, Phase III, New Delhi 110 020, India. Electronic address: jaspreet@iiitd.ac.in.
  • Kumar V; DAILAB, Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi 110 016, India. Electronic address: vipul.kumar@dbeb.iitd.ac.in.
  • Garg S; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: sukant.garg@aist.go.jp.
  • Subramani C; Regional Centre for Biotechnology (RCB), Faridabad 121 001, India. Electronic address: s.chandru@rcb.res.in.
  • Agarwal S; Regional Centre for Biotechnology (RCB), Faridabad 121 001, India. Electronic address: shubhra.agarwal@rcb.res.in.
  • Wang J; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: wang-jia0819@aist.go.jp.
  • Zhang H; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: zhang-huayue@aist.go.jp.
  • Kaul A; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: ashish-kaul@aist.go.jp.
  • Kalra RS; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: rajkumar-singh@oist.jp.
  • Kaul SC; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: s-kaul@aist.go.jp.
  • Vrati S; Regional Centre for Biotechnology (RCB), Faridabad 121 001, India. Electronic address: vrati@rcb.res.in.
  • Sundar D; DAILAB, Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi 110 016, India. Electronic address: sundar@dbeb.iitd.ac.in.
  • Wadhwa R; AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan. Electronic address: renu-wadhwa@aist.go.jp.
Int J Biol Macromol ; 184: 297-312, 2021 Aug 01.
Article in English | MEDLINE | ID: covidwho-1265684
ABSTRACT
COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the absence of drugs and vaccine, and premises of time, efforts and cost required for their development, natural resources such as herbs are anticipated to provide some help and may also offer a promising resource for drug development. Here, we have investigated the therapeutic prospective of Ashwagandha for the COVID-19 pandemic. Nine withanolides were tested in silico for their potential to target and inhibit (i) cell surface receptor protein (TMPRSS2) that is required for entry of virus to host cells and (ii) viral protein (the main protease Mpro) that is essential for virus replication. We report that the withanolides possess capacity to inhibit the activity of TMPRSS2 and Mpro. Furthermore, withanolide-treated cells showed downregulation of TMPRSS2 expression and inhibition of SARS-CoV-2 replication in vitro, suggesting that Ashwagandha may provide a useful resource for COVID-19 treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Serine Endopeptidases / Plant Extracts / Viral Matrix Proteins / Withanolides / SARS-CoV-2 Type of study: Observational study / Prognostic study Topics: Traditional medicine / Vaccines Limits: Humans Language: English Journal: Int J Biol Macromol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Serine Endopeptidases / Plant Extracts / Viral Matrix Proteins / Withanolides / SARS-CoV-2 Type of study: Observational study / Prognostic study Topics: Traditional medicine / Vaccines Limits: Humans Language: English Journal: Int J Biol Macromol Year: 2021 Document Type: Article