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Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells.
Calandria, Jorgelina M; Bhattacharjee, Surjyadipta; Maness, Nicholas J; Kautzmann, Marie-Audrey I; Asatryan, Aram; Gordon, William C; Do, Khanh V; Jun, Bokkyoo; Mukherjee, Pranab K; Petasis, Nicos A; Bazan, Nicolas G.
  • Calandria JM; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Bhattacharjee S; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Maness NJ; Tulane National Primate Research Center, Covington, LA, USA.
  • Kautzmann MI; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Asatryan A; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Gordon WC; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Do KV; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Jun B; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Mukherjee PK; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Petasis NA; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA.
  • Bazan NG; Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Sci Rep ; 11(1): 12324, 2021 06 10.
Article in English | MEDLINE | ID: covidwho-1265975
ABSTRACT
The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA, n-3) activate ELV biosynthesis in lung cells. Both ELVs and their precursors reduce the binding to RBD. ELVs downregulate angiotensin-converting enzyme 2 (ACE2) and enhance the expression of a set of protective proteins hindering cell surface virus binding and upregulating defensive proteins against lung damage. In addition, ELVs and their precursors decreased the signal of spike (S) protein found in SARS-CoV-2 infected cells, suggesting that the lipids curb viral infection. These findings open avenues for potential preventive and disease-modifiable therapeutic approaches for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Signal Transduction / Virus Internalization / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-91794-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Signal Transduction / Virus Internalization / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-91794-z