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Neurologic Manifestations of the Antiphospholipid Syndrome - an Update.
Leal Rato, Miguel; Bandeira, Matilde; Romão, Vasco C; Aguiar de Sousa, Diana.
  • Leal Rato M; Neurology, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal.
  • Bandeira M; Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • Romão VC; Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
  • Aguiar de Sousa D; Rheumatology Research Unit, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Curr Neurol Neurosci Rep ; 21(8): 41, 2021 Jun 14.
Article in English | MEDLINE | ID: covidwho-1267512
ABSTRACT
PURPOSE OF REVIEW In recent years, the spectrum of neurological manifestations of antiphospholipid syndrome (APS) has been growing. We provide a critical review of the literature with special emphasis on presentation, proposed mechanisms of disease, and treatment of neurological involvement in APS. RECENT

FINDINGS:

Although stroke is the most common cause of neurological manifestations in patients with APS, other neurological disorders have been increasingly associated with the disease, including cognitive dysfunction, headache, and epilepsy. Direct oral anticoagulants have failed to show non-inferiority compared to vitamin K antagonists for the prevention of major thrombotic events. Antiphospholipid antibodies are often found in patients with acute COVID-19 but clear evidence supporting an association between these antibodies and the risk of thrombotic events, including stroke and cerebral venous thrombosis, is still lacking. APS patients may present with several distinct neurological manifestations. New criteria will facilitate the classification of patients presenting with increasingly recognized non-criteria neurological manifestations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiphospholipid Syndrome / COVID-19 Type of study: Diagnostic study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Curr Neurol Neurosci Rep Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: S11910-021-01124-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiphospholipid Syndrome / COVID-19 Type of study: Diagnostic study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Curr Neurol Neurosci Rep Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: S11910-021-01124-z