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A time-resolved proteomic and prognostic map of COVID-19.
Demichev, Vadim; Tober-Lau, Pinkus; Lemke, Oliver; Nazarenko, Tatiana; Thibeault, Charlotte; Whitwell, Harry; Röhl, Annika; Freiwald, Anja; Szyrwiel, Lukasz; Ludwig, Daniela; Correia-Melo, Clara; Aulakh, Simran Kaur; Helbig, Elisa T; Stubbemann, Paula; Lippert, Lena J; Grüning, Nana-Maria; Blyuss, Oleg; Vernardis, Spyros; White, Matthew; Messner, Christoph B; Joannidis, Michael; Sonnweber, Thomas; Klein, Sebastian J; Pizzini, Alex; Wohlfarter, Yvonne; Sahanic, Sabina; Hilbe, Richard; Schaefer, Benedikt; Wagner, Sonja; Mittermaier, Mirja; Machleidt, Felix; Garcia, Carmen; Ruwwe-Glösenkamp, Christoph; Lingscheid, Tilman; Bosquillon de Jarcy, Laure; Stegemann, Miriam S; Pfeiffer, Moritz; Jürgens, Linda; Denker, Sophy; Zickler, Daniel; Enghard, Philipp; Zelezniak, Aleksej; Campbell, Archie; Hayward, Caroline; Porteous, David J; Marioni, Riccardo E; Uhrig, Alexander; Müller-Redetzky, Holger; Zoller, Heinz; Löffler-Ragg, Judith.
  • Demichev V; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK; The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge CB21GA, UK.
  • Tober-Lau P; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Lemke O; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
  • Nazarenko T; University College London, Department of Mathematics, London WC1E 6BT, UK; University College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK.
  • Thibeault C; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Whitwell H; National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW72AZ, UK; Lobachevsky University, Department of Applied Mathematics, Nizhny Novgorod 603105, Russia; Imperial College London, Section of Bioanalyt
  • Röhl A; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
  • Freiwald A; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
  • Szyrwiel L; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
  • Ludwig D; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
  • Correia-Melo C; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
  • Aulakh SK; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
  • Helbig ET; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Stubbemann P; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Lippert LJ; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Grüning NM; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
  • Blyuss O; Lobachevsky University, Department of Applied Mathematics, Nizhny Novgorod 603105, Russia; University of Hertfordshire, School of Physics, Astronomy and Mathematics, Hatfield AL10 9AB, UK; Sechenov First Moscow State Medical University, Department of Paediatrics and Paediatric Infectious Diseases, M
  • Vernardis S; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
  • White M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
  • Messner CB; Charité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
  • Joannidis M; Medical University Innsbruck, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, 6020 Innsbruck, Austria.
  • Sonnweber T; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
  • Klein SJ; Medical University Innsbruck, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, 6020 Innsbruck, Austria.
  • Pizzini A; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
  • Wohlfarter Y; Medical University of Innsbruck, Institute of Human Genetics, 6020 Innsbruck, Austria.
  • Sahanic S; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
  • Hilbe R; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
  • Schaefer B; Medical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
  • Wagner S; Medical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
  • Mittermaier M; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
  • Machleidt F; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Garcia C; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Ruwwe-Glösenkamp C; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Lingscheid T; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Bosquillon de Jarcy L; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Stegemann MS; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Pfeiffer M; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Jürgens L; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Denker S; Charité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology & Tumor Immunology, Virchow Campus & Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
  • Zickler D; Charité Universitätsmedizin Berlin, Department of Nephrology and Internal Intensive Care Medicine, 10117 Berlin, Germany.
  • Enghard P; Charité Universitätsmedizin Berlin, Department of Nephrology and Internal Intensive Care Medicine, 10117 Berlin, Germany.
  • Zelezniak A; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK; Chalmers Tekniska Högskola, Department of Biology and Biological Engineering, SE-412 96 Gothenburg, Sweden.
  • Campbell A; University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK; University of Edinburgh, Usher Institute, Edinburgh EH16 4UX, UK.
  • Hayward C; University of Edinburgh, MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK.
  • Porteous DJ; University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK; University of Edinburgh, Usher Institute, Edinburgh EH16 4UX, UK.
  • Marioni RE; University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK.
  • Uhrig A; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Müller-Redetzky H; Charité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
  • Zoller H; Medical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
  • Löffler-Ragg J; Medical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Cell Syst ; 12(8): 780-794.e7, 2021 08 18.
Article in English | MEDLINE | ID: covidwho-1267622
ABSTRACT
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Disease Progression / Proteome / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Cell Syst Year: 2021 Document Type: Article Affiliation country: J.cels.2021.05.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Disease Progression / Proteome / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Cell Syst Year: 2021 Document Type: Article Affiliation country: J.cels.2021.05.005