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SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.
Correa, Yubexi; Waldie, Sarah; Thépaut, Michel; Micciulla, Samantha; Moulin, Martine; Fieschi, Franck; Pichler, Harald; Trevor Forsyth, V; Haertlein, Michael; Cárdenas, Marité.
  • Correa Y; Biofilms - Research Center for Biointerfaces and Department of Biomedical Science, Faculty of Health and Society, Malmö University, 20506 Malmö, Sweden.
  • Waldie S; Biofilms - Research Center for Biointerfaces and Department of Biomedical Science, Faculty of Health and Society, Malmö University, 20506 Malmö, Sweden; Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France.
  • Thépaut M; Univ. Grenoble Alpes, CNRS, CEA, IBS, 71 avenue des Martyrs, F-38000 Grenoble, France.
  • Micciulla S; Large Scale Structures, Institut Laue Langevin (ILL), Grenoble F-38042, France.
  • Moulin M; Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France.
  • Fieschi F; Partnership for Structural Biology, Grenoble F-38042, France; Univ. Grenoble Alpes, CNRS, CEA, IBS, 71 avenue des Martyrs, F-38000 Grenoble, France.
  • Pichler H; Austrian Centre of Industrial Biotechnology, Petersgasse 14, 8010 Graz, Austria; Graz University of Technology, Institute of Molecular Biotechnology, NAWI Graz, BioTechMed Graz, Petersgasse 14, 8010 Graz, Austria.
  • Trevor Forsyth V; Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France; Faculty of Natural Sciences, Keele University, Staffordshire ST5 5BG, UK. Electronic address: forsyth@ill.fr.
  • Haertlein M; Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France. Electronic address: haertlein@ill.fr.
  • Cárdenas M; Biofilms - Research Center for Biointerfaces and Department of Biomedical Science, Faculty of Health and Society, Malmö University, 20506 Malmö, Sweden. Electronic address: marite.cardenas@mau.se.
J Colloid Interface Sci ; 602: 732-739, 2021 Nov 15.
Article in English | MEDLINE | ID: covidwho-1267733
ABSTRACT
Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection is also known to be correlated with lipid disorders. Furthermore, the levels of both serum cholesterol and high-density lipoprotein (HDL) decrease with Covid-19 severity, with normal levels resuming once the infection has passed. Here we demonstrate that the SARS-CoV-2 spike (S) protein interferes with the function of lipoproteins, and that this is dependent on cholesterol. In particular, the ability of HDL to exchange lipids from model cellular membranes is altered when co-incubated with the spike protein. Additionally, the S protein removes lipids and cholesterol from model membranes. We propose that the S protein affects HDL function by removing lipids from it and remodelling its composition/structure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Lipids / Lipoproteins, HDL Type of study: Prognostic study Limits: Humans Language: English Journal: J Colloid Interface Sci Year: 2021 Document Type: Article Affiliation country: J.jcis.2021.06.056

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Lipids / Lipoproteins, HDL Type of study: Prognostic study Limits: Humans Language: English Journal: J Colloid Interface Sci Year: 2021 Document Type: Article Affiliation country: J.jcis.2021.06.056