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Preparation and evaluation of benzalkonium chloride hand sanitizer as a potential alternative for alcohol-based hand gels.
Aodah, Alhassan H; Bakr, Abrar A; Booq, Rayan Y; Rahman, Mohammed J; Alzahrani, Dunia A; Alsulami, Khulud A; Alshaya, Hassa A; Alsuabeyl, Mohammed S; Alyamani, Essam J; Tawfik, Essam A.
  • Aodah AH; National Centre for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Bakr AA; National Centre for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Booq RY; National Centre for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Rahman MJ; National Centre for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Alzahrani DA; National Centre for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Alsulami KA; National Centre for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Alshaya HA; National Centre for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Alsuabeyl MS; King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Alyamani EJ; National Centre for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
  • Tawfik EA; National Centre for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), 6086, Riyadh 11442, Saudi Arabia.
Saudi Pharm J ; 29(8): 807-814, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1267764
ABSTRACT
Hand hygiene is one of the effective measures for reducing the transmission of infections. Alcohol-based hand sanitizers containing ethanol or isopropanol are considered efficient alternatives to handwashing with water and soap. Despite being effective against a broad-spectrum of microbes, fining an effective alternative to the alcohol-based hand sanitizers became a necessity owning to the limitations associated with their use, such as skin dryness, irritant contact dermatitis, and intoxication upon their accidental ingestion. Furthermore, in certain circumstances when the demand for alcohol exceeds the supply, like in the current COVID19 pandemic, formulating an effective non-alcoholic hand sanitizer would be a potential solution. Therefore, in this study, a non-alcoholic hand sanitizer containing benzalkonium chloride (BKC) as an active ingredient was prepared and evaluated as a less irritant and more persistent hand sanitizer gel. The hand gel was characterized by pH, viscosity, and spreadability. Results showed that this product has low viscosity, high spreadability and pH of 6.3, which is less likely to cause skin irritation. The antibacterial assessment (zone of inhibition) of the BKC-based hand sanitizer demonstrated antibacterial activities against nine out of eleven gram-positive and gram-negative bacterial strains, while the acceptability study on ten participants showed no signs of skin irritation nor redness upon its application. Consequently, this non-alcoholic based hand sanitizer is suggested as a potential alternative to alcohol-based hand gels.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal: Saudi Pharm J Year: 2021 Document Type: Article Affiliation country: J.jsps.2021.06.002

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal: Saudi Pharm J Year: 2021 Document Type: Article Affiliation country: J.jsps.2021.06.002