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Adaptive lymphocyte profile analysis discriminates mild and severe forms of COVID-19 after solid organ transplantation.
Del Bello, Arnaud; Kamar, Nassim; Vergez, Francois; Faguer, Stanislas; Marion, Olivier; Beq, Audrey; Lathrache, Yasmine; Abravanel, Florence; Izopet, Jacques; Treiner, Emmanuel.
  • Del Bello A; Département de Néphrologie, Dialyse et Transplantation d'Organes, Centre Hospitalier et Universitaire de Toulouse, Toulouse, France; Institut National de la Santé et de la Recherche Médicale - Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043 - CNRS 5282, Toulouse, France; Université Paul
  • Kamar N; Département de Néphrologie, Dialyse et Transplantation d'Organes, Centre Hospitalier et Universitaire de Toulouse, Toulouse, France; Institut National de la Santé et de la Recherche Médicale - Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043 - CNRS 5282, Toulouse, France; Université Paul
  • Vergez F; Université Paul Sabatier Toulouse III, Toulouse, France; Laboratoire d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France; Institut National de la Santé et de la Recherche Médicale - Centre de Recherche en Cancérologie d
  • Faguer S; Département de Néphrologie, Dialyse et Transplantation d'Organes, Centre Hospitalier et Universitaire de Toulouse, Toulouse, France; Université Paul Sabatier Toulouse III, Toulouse, France; Institut National de la Santé et de la Recherche Médicale - Institut des Maladies Métaboliques et Cardiovascul
  • Marion O; Département de Néphrologie, Dialyse et Transplantation d'Organes, Centre Hospitalier et Universitaire de Toulouse, Toulouse, France; Institut National de la Santé et de la Recherche Médicale - Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043 - CNRS 5282, Toulouse, France; Université Paul
  • Beq A; Département de Néphrologie, Dialyse et Transplantation d'Organes, Centre Hospitalier et Universitaire de Toulouse, Toulouse, France.
  • Lathrache Y; Laboratory of Immunology, Biology Department, CHU Toulouse, Toulouse, France.
  • Abravanel F; Institut National de la Santé et de la Recherche Médicale - Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043 - CNRS 5282, Toulouse, France; Université Paul Sabatier Toulouse III, Toulouse, France; Laboratory of Virology, Biology Department, CHU Toulouse, Toulouse, France.
  • Izopet J; Institut National de la Santé et de la Recherche Médicale - Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043 - CNRS 5282, Toulouse, France; Université Paul Sabatier Toulouse III, Toulouse, France; Laboratory of Virology, Biology Department, CHU Toulouse, Toulouse, France.
  • Treiner E; Institut National de la Santé et de la Recherche Médicale - Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043 - CNRS 5282, Toulouse, France; Université Paul Sabatier Toulouse III, Toulouse, France; Laboratory of Immunology, Biology Department, CHU Toulouse, Toulouse, France.
Kidney Int ; 100(4): 915-927, 2021 10.
Article in English | MEDLINE | ID: covidwho-1267774
ABSTRACT
Solid organ transplant recipients are at high risk for the development of severe forms of COVID-19. However, the role of immunosuppression in the morbidity and mortality of the immune phenotype during COVID-19 in transplant recipients remains unknown. In this retrospective study, we compared peripheral blood T and B cell functional and surface markers, as well as serum antibody development during 29 cases of mild (World Health Organization 9-point Ordinal Scale (WOS) of 3-4) and 22 cases of severe COVID-19 (WOS 5-8) in solid organ transplant (72% kidney transplant) recipients hospitalized in our center. Patients who developed severe forms of COVID-19 presented significantly lower CD3+ (median 344/mm3 (inter quartile range 197; 564) vs. 643/mm3 (397; 1251)) and CD8+ T cell counts (124/mm3 (76; 229) vs. 240/mm3 (119; 435)). However, activated CD4+ T cells were significantly more frequent in severe forms (2.9% (1.37; 5.72) vs. 1.4% (0.68; 2.35)), counterbalanced by a significantly higher proportion of Tregs (3.9% (2.35; 5.87) vs. 2.7% (1.9; 3.45)). A marked decrease in the proportion of NK cells was noted only in severe forms. In the B cell compartment, transitional B cells were significantly lower in severe forms (1.2% (0.7; 4.2) vs. 3.6% (2.1; 6.2)). Nonetheless, a majority of transplant recipients developed antibodies against SARS-CoV-2 (77% and 83% in mild and severe forms, respectively). Thus, our data revealed immunological differences between mild and severe forms of COVID-19 in solid organ transplant recipients, similar to previous reports in the immunocompetent population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Kidney Int Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Kidney Int Year: 2021 Document Type: Article