Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2.
Cell Rep Med
; 2(7): 100327, 2021 07 20.
Article
in English
| MEDLINE | ID: covidwho-1275765
ABSTRACT
Severe COVID-19 appears rare in children. This is unexpected, especially in young infants, who are vulnerable to severe disease caused by other respiratory viruses. We evaluate convalescent immune responses in 4 infants under 3 months old with confirmed COVID-19 who presented with mild febrile illness, alongside their parents, and adult controls recovered from confirmed COVID-19. Although not statistically significant, compared to seropositive adults, infants have high serum levels of IgG and IgA to SARS-CoV-2 spike protein, with a corresponding functional ability to block SARS-CoV-2 cellular entry. Infants also exhibit robust saliva anti-spike IgG and IgA responses. Spike-specific IFN-γ production by infant peripheral blood mononuclear cells appears restrained, but the frequency of spike-specific IFN-γ- and/or TNF-α-producing T cells is comparable between infants and adults. On principal-component analysis, infant immune responses appear distinct from their parents. Robust functional antibody responses alongside restrained IFN-γ production may help protect infants from severe COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interferon-gamma
/
Spike Glycoprotein, Coronavirus
/
COVID-19
/
Antibody Formation
Type of study:
Experimental Studies
Limits:
Adult
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
/
Young adult
Language:
English
Journal:
Cell Rep Med
Year:
2021
Document Type:
Article
Affiliation country:
J.xcrm.2021.100327
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