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Potent and Persistent Antibody Response in COVID-19 Recovered Patients.
Tian, Xiaodong; Liu, Ling; Jiang, Wenguo; Zhang, He; Liu, Wenjun; Li, Jing.
  • Tian X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Liu L; School of Life Sciences, University of Science and Technology of China, Hefei, China.
  • Jiang W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Zhang H; Institutes of Physical Science and Information Technology, Anhui University, Hefei, China.
  • Liu W; Jining Center for Disease Control and Prevention, Shandong, China.
  • Li J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Front Immunol ; 12: 659041, 2021.
Article in English | MEDLINE | ID: covidwho-1268250
ABSTRACT
SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Virus-specific antibodies can be detected in infected patients approximately two weeks after symptom onset. In this study, we set up ELISA technology coating with purified SARS-CoV-2 S and N proteins to study the antibody response of 484 serum samples. We established a surrogate viral inhibition assay using SARS-CoV-2 S protein pseudovirus system to determine the neutralization potency of collected serum samples. Here, we report robust antibody responses to SARS-CoV-2 in 484 recovered patients varying from 154 to 193 days, with 92% of recovered patients displaying a positive virus-specific spike glycoprotein IgG (s-IgG) response, while the ratio of positive spike glycoprotein IgM (s-IgM) reached 63%. Furthermore, moderate to potent neutralization activities were also observed in 62% of patients, correlating significantly with s-IgG response. This study strongly supports the long-term presence of antibodies in recovered patients against SARS-CoV-2, although all serum samples were collected from individuals with mild or moderate symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Long Covid Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.659041

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Long Covid Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.659041