Your browser doesn't support javascript.
Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury.
Zhu, Dan-Dan; Tan, Xue-Mei; Lu, Li-Qing; Yu, Si-Jia; Jian, Ru-Li; Liang, Xin-Fang; Liao, Yi-Xuan; Fan, Wei; Barbier-Torres, Lucíia; Yang, Austin; Yang, He-Ping; Liu, Ting.
  • Zhu DD; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Tan XM; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Lu LQ; Key Laboratory of Cancer proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Yu SJ; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Jian RL; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Liang XF; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Liao YX; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
  • Fan W; Department of Medicine, Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • Barbier-Torres L; Department of Medicine, Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • Yang A; Department of Biology, East Los Angeles College, Los Angeles, CA 91008, United States.
  • Yang HP; Department of Medicine, Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • Liu T; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. liuting818@126.com.
World J Gastroenterol ; 27(22): 2944-2962, 2021 Jun 14.
Article in English | MEDLINE | ID: covidwho-1268364
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammation Mediators / NF-E2-Related Factor 2 / COVID-19 / Liver Diseases Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: Wjg.v27.i22.2944

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammation Mediators / NF-E2-Related Factor 2 / COVID-19 / Liver Diseases Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: Wjg.v27.i22.2944