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Low-dose radiotherapy for COVID 19: A radioimmunological perspective.
Kumar, Rishabh; Haresh, Kunhi Parambath; Sharma, Daya Nand; Gupta, Anil; Gupta, Subhash; Vellaiyan, Subramani; Rath, Goura Kishor.
  • Kumar R; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Haresh KP; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Sharma DN; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi; Department of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India.
  • Gupta A; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Gupta S; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Vellaiyan S; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Rath GK; Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi; Department of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India.
J Cancer Res Ther ; 17(2): 295-302, 2021.
Article in English | MEDLINE | ID: covidwho-1268380
ABSTRACT
The world is fighting the onslaught of COVID 19 for the last 10 months, ever since the first case was reported in December 2019 in Wuhan, China. Now, it has spread to over 200 countries. COVID 19-associated respiratory syndrome is causing a lot of mortality and morbidity. There are reports suggesting that the complications and ARDS associated with COVID 19 is an immune response reaction. The cytokine storm associated with severe cases of COVID 19 acts as a cause of death in many sick patients. It has been shown that COVID 19 is associated with a peculiar immune profile Decrease in CD3, CD4, CD8, natural killer cell and B-cells; Rise in interleukin (IL)-4, IL-6 and tumor necrosis factor (TNF) alpha; Decrease in IL-10; Decrease in interferon-gamma. Low-dose radiotherapy (LDRT) immunosuppressive features resulting from M2 macrophage phenotype activation, increase in IL-10, transforming growth factor beta, a decrease in IL-6, TNF alpha and an increase in CD3, CD4, and CD8 T cell counts may negate the harmful effects of cytokine release syndrome. Literature review shows that radiation was previously used to treat viral pneumonia with a good success rate. This practice was discontinued in view of the availability of effective antibiotics and antivirals. As there are no scientifically proven treatment for severe COVID 19-associated respiratory distress today, it is prudent that we understand the benefits of LDRT at this critical juncture and take rational decisions to treat the same. This article provides an radioimmunological rationale for the treatment of immune crisis mediated complications in severe cases of COVID 19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunosuppression Therapy / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: J Cancer Res Ther Journal subject: Neoplasms / Therapeutics Year: 2021 Document Type: Article Affiliation country: Jcrt.JCRT_1045_20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunosuppression Therapy / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: J Cancer Res Ther Journal subject: Neoplasms / Therapeutics Year: 2021 Document Type: Article Affiliation country: Jcrt.JCRT_1045_20