Your browser doesn't support javascript.
A Meta-analysis on the Role of Children in Severe Acute Respiratory Syndrome Coronavirus 2 in Household Transmission Clusters.
Zhu, Yanshan; Bloxham, Conor J; Hulme, Katina D; Sinclair, Jane E; Tong, Zhen Wei Marcus; Steele, Lauren E; Noye, Ellesandra C; Lu, Jiahai; Xia, Yao; Chew, Keng Yih; Pickering, Janessa; Gilks, Charles; Bowen, Asha C; Short, Kirsty R.
  • Zhu Y; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Bloxham CJ; School of Biomedical Science, The University of Queensland, Brisbane, Australia.
  • Hulme KD; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Sinclair JE; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Tong ZWM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Steele LE; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Noye EC; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Lu J; One Health Center of Excellence for Research and Training, Department of epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
  • Xia Y; School of Science, Edith Cowan University, Australia; School of Biomedical Science, The University of Western Australia, Perth, Australia.
  • Chew KY; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Pickering J; Wesfarmer's Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, Perth, Western Australia.
  • Gilks C; School of Public Health, The University of Queensland, Brisbane, Australia.
  • Bowen AC; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia.
  • Short KR; Wesfarmer's Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, Perth, Western Australia.
Clin Infect Dis ; 72(12): e1146-e1153, 2021 06 15.
Article in English | MEDLINE | ID: covidwho-1269565
ABSTRACT
The role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains highly controversial. To address this issue, we performed a meta-analysis of the published literature on household SARS-CoV-2 transmission clusters (n = 213 from 12 countries). Only 8 (3.8%) transmission clusters were identified as having a pediatric index case. Asymptomatic index cases were associated with a lower secondary attack in contacts than symptomatic index cases (estimate risk ratio [RR], 0.17; 95% confidence interval [CI], 0.09-0.29). To determine the susceptibility of children to household infections the secondary attack rate in pediatric household contacts was assessed. The secondary attack rate in pediatric household contacts was lower than in adult household contacts (RR, 0.62; 95% CI, 0.42-0.91). These data have important implications for the ongoing management of the COVID-19 pandemic, including potential vaccine prioritization strategies.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Reviews Topics: Vaccines Limits: Adult / Child / Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Reviews Topics: Vaccines Limits: Adult / Child / Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid