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COVID-19 and pediatric fatty liver disease: Is there interplay?
Di Sessa, Anna; Lanzaro, Francesca; Zarrilli, Sarah; Picone, Vittorio; Guarino, Stefano; Miraglia Del Giudice, Emanuele; Marzuillo, Pierluigi.
  • Di Sessa A; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy. anna.disessa@libero.it.
  • Lanzaro F; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy.
  • Zarrilli S; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy.
  • Picone V; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy.
  • Guarino S; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy.
  • Miraglia Del Giudice E; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy.
  • Marzuillo P; Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli," Naples 80138, Italy.
World J Gastroenterol ; 27(22): 3064-3072, 2021 Jun 14.
Article in English | MEDLINE | ID: covidwho-1270140
ABSTRACT
The rapid global spread of coronavirus disease 2019 (COVID-19) infection has become a major health issue with higher morbidity and mortality rates. Besides respiratory symptoms, a growing body of evidence indicates a variety of gastrointestinal manifestations including liver involvement. In this regard, several data supported an association between COVID-19 infection and liver injury in adults, while in children there is compelling but currently limited evidence. In particular, patients with COVID-19 have shown a higher risk of liver injury (mainly expressed as increased transaminase levels or hepatic steatosis). Conversely, a greater risk of more severe forms of COVID-19 infection has been observed in subjects with pre-existing chronic liver diseases. The dramatic interplay between COVID-19 and liver damage has been related to the inflammatory pathways chronically active in patients with nonalcoholic fatty liver disease and acutely in those affected by COVID-19, but other different pathogenic mechanisms have also been supposed. Of note, patients with previous metabolic comorbidities also had a higher risk of severe COVID-19 infection. This emphasizes the pathogenic interrelation of the inflammatory pathways with a dysregulated metabolic milieu in COVID-19 patients. Taking into account the prognostic role of fatty liver in COVID-19 patients and its intrinsic relationship with metabolic abnormalities even in childhood, a strict monitoring of this condition is recommended. We aimed to summarize the most recent evidence regarding the potential interplay between pediatric fatty liver and COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / COVID-19 Type of study: Observational study / Prognostic study Limits: Child / Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: Wjg.v27.i22.3064

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / COVID-19 Type of study: Observational study / Prognostic study Limits: Child / Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: Wjg.v27.i22.3064