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Immature platelets as a biomarker for disease severity and mortality in COVID-19 patients.
Welder, Daniel; Jeon-Slaughter, Haekyung; Ashraf, Bilal; Choi, Sung-Hee; Chen, Weina; Ibrahim, Ibrahim; Bat, Taha.
  • Welder D; Department of Pathology, Hematopathology Section, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Jeon-Slaughter H; Department of Internal Medicine, VA North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Ashraf B; Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Choi SH; Department of Internal Medicine, VA North Texas Health Care System and Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chen W; Department of Pathology, Hematopathology Section, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Ibrahim I; Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Bat T; Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Br J Haematol ; 194(3): 530-536, 2021 08.
Article in English | MEDLINE | ID: covidwho-1270823
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
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2. 2019 novel coronavirus CAUSES COVID-19
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2019 novel coronavirus
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3. Cessation of life PROCESS_OF Patients
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Cessation of life
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4. Pulmonary Fibrosis PROCESS_OF Patients
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5. COVID-19 PROCESS_OF Patients
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6. 2019 novel coronavirus CAUSES COVID-19
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7. Cessation of life PROCESS_OF Patients
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Cessation of life
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8. Pulmonary Fibrosis PROCESS_OF Patients
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Pulmonary Fibrosis
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ABSTRACT
COVID-19, caused by SARS-CoV-2, is a contagious life-threatening viral disease that has killed more than three million people worldwide to date. Attempts have been made to identify biomarker(s) to stratify disease severity and improve treatment and resource allocation. Patients with SARS-COV-2 infection manifest with a higher inflammatory response and platelet hyperreactivity; this raises the question of the role of thrombopoiesis in COVID-19 infection. Immature platelet fraction (IPF, %) and immature platelet counts (IPC, ×109 /l) can be used to assess thrombopoiesis. This study investigates whether the level of thrombopoiesis correlates with COVID-19 severity. A large cohort of 678 well-characterized COVID-19 patients was analyzed, including 658 (97%) hospitalized and 139 (21%) admitted to the intensive care unit (ICU). Elevated percentage IPF at presentation was predictive of length of hospitalization (P < 0·01) and ICU admission (P < 0·05). Additionally, percentage IPF at the peak was significantly higher among ICU patients than non-ICU patients (6·9 ± 5·1 vs 5·3 ± 8·4, P < 0·01) and among deceased patients than recovered patients (7·9 ± 6·3 vs 5·4 ± 7·8, P < 0·01). Furthermore, IPC at the peak was significantly higher among ICU patients than non-ICU patients (18·5 ± 16·2 vs. 13·2 ± 8·3, P < 0·05) and among patients on a ventilator than those not (22·1 ± 20·1 vs.13·4 ± 8·4, P < 0·05). Our study demonstrated that elevated initial and peak values of percentage IPF and IPC might serve as prognostic biomarkers for COVID-19 progression to severe conditions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Platelets / Thrombopoiesis / COVID-19 Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2021 Document Type: Article Affiliation country: Bjh.17656

Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Platelets / Thrombopoiesis / COVID-19 Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2021 Document Type: Article Affiliation country: Bjh.17656