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Long non-coding RNA: An underlying bridge linking neuroinflammation and central nervous system diseases.
Chen, Zhuohui; Wu, Haiyue; Zhang, Mengqi.
  • Chen Z; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Wu H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Zhang M; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address: zhangmengqi8912@163.com.
Neurochem Int ; 148: 105101, 2021 09.
Article in English | MEDLINE | ID: covidwho-1271730
ABSTRACT
Central nervous system (CNS) diseases are responsible for a large proportion of morbidity and mortality worldwide. CNS diseases caused by intrinsic and extrinsic stimuli stimulate the resident immune cells including microglia and astrocyte, resulting in neuroinflammation that exacerbates the progression of diseases. Recent evidence reveals the aberrant expression patterns of long non-coding RNAs (lncRNAs) in the damaged tissues following CNS diseases. It was also proposed that lncRNAs possessed immune-modulatory activities by directly or indirectly affecting various effector proteins including transcriptional factor, acetylase, protein kinase, phosphatase, etc. In addition, lncRNAs can form a sophisticated network by interacting with other molecules to regulate the expression or activation of downstream immune response pathways. However, the major roles of lncRNAs in CNS pathophysiologies are still elusive, especially in neuroinflammation. Herein, we tend to review some potential roles of lncRNAs in modulating neuroinflammation based on current evidence in various CNS diseases, in order to provide novel explanations for the initiation and progression of CNS diseases and help to establish therapeutic strategies targeting neuroinflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Central Nervous System Diseases / RNA, Long Noncoding / Neuroinflammatory Diseases Limits: Animals / Humans Language: English Journal: Neurochem Int Year: 2021 Document Type: Article Affiliation country: J.neuint.2021.105101

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Central Nervous System Diseases / RNA, Long Noncoding / Neuroinflammatory Diseases Limits: Animals / Humans Language: English Journal: Neurochem Int Year: 2021 Document Type: Article Affiliation country: J.neuint.2021.105101