From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Protein Interactions.
Chem Rec
; 21(11): 3087-3101, 2021 Nov.
Article
in English
| MEDLINE | ID: covidwho-1272237
ABSTRACT
Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate a vast array of biological and pathological processes. Inhibition of HS-protein interactions is thus an attractive approach for new therapeutic development for cancer and infectious diseases, including COVID-19; however, synthesis of well-defined native HS oligosaccharides remains challenging. This has aroused significant interest in the development of HS mimetics which are more synthetically tractable and have fewer side effects, such as undesired anticoagulant activity. This account provides a perspective on the design and synthesis of different classes of HS mimetics with useful properties, and the development of various assays and molecular modelling tools to progress our understanding of their interactions with HS-binding proteins.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Chem Rec
Journal subject:
Chemistry
Year:
2021
Document Type:
Article
Affiliation country:
Tcr.202100125
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