Generating hard-to-obtain information from easy-to-obtain information: Applications in drug discovery and clinical inference.
Patterns (N Y)
; 2(7): 100288, 2021 Jul 09.
Article
in English
| MEDLINE | ID: covidwho-1272655
ABSTRACT
Often when biological entities are measured in multiple ways, there are distinct categories of information some information is easy-to-obtain information (EI) and can be gathered on virtually every subject of interest, while other information is hard-to-obtain information (HI) and can only be gathered on some. We propose building a model to make probabilistic predictions of HI using EI. Our feature mapping GAN (FMGAN), based on the conditional GAN framework, uses an embedding network to process conditions as part of the conditional GAN training to create manifold structure when it is not readily present in the conditions. We experiment on generating RNA sequencing of cell lines perturbed with a drug conditioned on the drug's chemical structure and generating FACS data from clinical monitoring variables on a cohort of COVID-19 patients, effectively describing their immune response in great detail.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Patterns (N Y)
Year:
2021
Document Type:
Article
Affiliation country:
J.patter.2021.100288
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