Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data.
Diabet Med
; 38(11): e14608, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1273085
ABSTRACT
AIMS:
Aim of this study is to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, responsible for coronavirus disease 2019 (COVID-19), as a possible cause for type 1 diabetes by providing an illustrative clinical case of a man aged 45 years presenting with antibody-negative diabetic ketoacidosis post-recovery from COVID-19 pneumonia and to explore the potential for SARS-CoV-2 to adhere to human islet cells.METHODS:
Explanted human islet cells from three independent solid organ donors were incubated with the SARS-CoV-2 spike protein receptor biding domain (RBD) fused to a green fluorescent protein (GFP) or a control-GFP, with differential adherence established by flow cytometry.RESULTS:
Flow cytometry revealed dose-dependent specific binding of RBD-GFP to islet cells when compared to control-GFP.CONCLUSIONS:
Although a causal basis remains to be established, our case and in vitro data highlight a potential mechanism by which SARS-CoV-2 infection may result in antibody-negative type 1 diabetes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Islets of Langerhans
/
Diabetic Ketoacidosis
/
Diabetes Mellitus, Type 1
/
Spike Glycoprotein, Coronavirus
/
SARS-CoV-2
/
COVID-19
Type of study:
Case report
/
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Diabet Med
Journal subject:
Endocrinology
Year:
2021
Document Type:
Article
Affiliation country:
Dme.14608
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