COVID-19 and celiac disease: A pathogenetic hypothesis for a celiac outbreak.
Int J Clin Pract
; 75(9): e14452, 2021 Sep.
Article
in English
| MEDLINE | ID: covidwho-1273092
ABSTRACT
BACKGROUND:
A growing body of evidence supports the intestinal trophism of SARS-CoV-2, with ciliated cells and intestinal enterocytes being target cells because of the high expression of ACE2 and TMPRSS2. Indeed, COVID-19 promotes a "cytokine storm" in the intestinal mucosa the resulting epithelial damage leads to increased barrier permeability, allowing the passage of gliadin in the intestinal lamina.METHODS:
Based on current literature, we hypothesize the role of COVID-19 as a potential trigger factor for celiac disease in predisposed patients.CONCLUSIONS:
Genetically predisposed patients could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a candidate culprit for a potential outbreak of celiac disease in the forthcoming future.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Celiac Disease
/
COVID-19
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Int J Clin Pract
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Ijcp.14452
Similar
MEDLINE
...
LILACS
LIS