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The Role of Th17 Response in COVID-19.
Martonik, Diana; Parfieniuk-Kowerda, Anna; Rogalska, Magdalena; Flisiak, Robert.
  • Martonik D; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 15-540 Bialystok, Poland.
  • Parfieniuk-Kowerda A; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 15-540 Bialystok, Poland.
  • Rogalska M; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 15-540 Bialystok, Poland.
  • Flisiak R; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 15-540 Bialystok, Poland.
Cells ; 10(6)2021 06 19.
Article in English | MEDLINE | ID: covidwho-1273394
ABSTRACT
COVID-19 is an acute infectious disease of the respiratory system caused by infection with the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission of SARS-CoV-2 infections occurs through droplets and contaminated objects. A rapid and well-coordinated immune system response is the first line of defense in a viral infection. However, a disturbed and over-activated immune response may be counterproductive, causing damage to the body. Severely ill patients hospitalised with COVID-19 exhibit increased levels of many cytokines, including Interleukin (IL)-1ß, IL-2, IL-6, IL-7, IL-8, IL-10, IL-17, granulocyte colony stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP-1) and tumor necrosis factor (TNF). Increasing evidence suggests that Th17 cells play an important role in the pathogenesis of COVID-19, not only by activating cytokine cascade but also by inducing Th2 responses, inhibiting Th1 differentiation and suppressing Treg cells. This review focuses on a Th17 pathway in the course of the immune response in COVID-19, and explores plausible targets for therapeutic intervention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Th17 Cells / COVID-19 / Immunity, Cellular Type of study: Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10061550

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Th17 Cells / COVID-19 / Immunity, Cellular Type of study: Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10061550