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Should countries switch to using five- or ten-dose rotavirus vaccines now that they are available?
Wedlock, Patrick T; Cox, Sarah N; Bartsch, Sarah M; Randall, Samuel L; O'Shea, Kelly J; Ferguson, Marie C; Siegmund, Sheryl S; Lee, Bruce Y.
  • Wedlock PT; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • Cox SN; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • Bartsch SM; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • Randall SL; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • O'Shea KJ; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • Ferguson MC; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • Siegmund SS; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA.
  • Lee BY; Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy, New York City, NY, USA. Electronic address: bruceleemdmba@gmail.com.
Vaccine ; 39(31): 4335-4342, 2021 07 13.
Article in English | MEDLINE | ID: covidwho-1274451
ABSTRACT

INTRODUCTION:

Single-dose rotavirus vaccines, which are used by a majority of countries, are some of the largest-sized vaccines in immunization programs, and have been shown to constrain supply chains and cause bottlenecks. Efforts have been made to reduce the size of the single-dose vaccines; however, with two-dose, five-dose and ten-dose options available, the question then is whether using multi-dose instead of single-dose rotavirus vaccines will improve vaccine availability.

METHODS:

We used HERMES-generated simulation models of the vaccine supply chains of the Republic of Benin, Mozambique, and Bihar, a state in India, to evaluate the operational and economic impact of implementing each of the nine different rotavirus vaccine presentations.

RESULTS:

Among single-dose rotavirus vaccines, using Rotarix RV1 MMP (multi-monodose presentation) led to the highest rotavirus vaccine availability (49-80%) and total vaccine availability (56-79%), and decreased total costs per dose administered ($0.02-$0.10) compared to using any other single-dose rotavirus vaccine. Using two-dose ROTASIIL decreased rotavirus vaccine availability by 3-6% across each supply chain compared to Rotarix RV1 MMP, the smallest single-dose vaccine. Using a five-dose rotavirus vaccine improved rotavirus vaccine availability (52-92%) and total vaccine availability (60-85%) compared to single-dose and two-dose vaccines. Further, using the ten-dose vaccine led to the highest rotavirus vaccine availability compared to all other rotavirus vaccines in both Benin and Bihar.

CONCLUSION:

Our results show that countries that implement five-dose or ten-dose rotavirus vaccines consistently reduce cold chain constraints and achieve higher rotavirus and total vaccine availability compared to using either single-dose or two-dose rotavirus vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rotavirus Infections / Rotavirus / Rotavirus Vaccines Type of study: Experimental Studies Topics: Vaccines Limits: Humans / Infant Country/Region as subject: Africa / Asia Language: English Journal: Vaccine Year: 2021 Document Type: Article Affiliation country: J.vaccine.2021.06.021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rotavirus Infections / Rotavirus / Rotavirus Vaccines Type of study: Experimental Studies Topics: Vaccines Limits: Humans / Infant Country/Region as subject: Africa / Asia Language: English Journal: Vaccine Year: 2021 Document Type: Article Affiliation country: J.vaccine.2021.06.021