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SARS-CoV-2 seroconversions and chains of infection in healthcare professionals in a German maximum care provider (The CoSHeP study).
van Bremen, Kathrin; Monin, Malte; Eis-Hübinger, Anna Maria; Marx, Benjamin; Aldabaggh, Souhaib; Streeck, Hendrik; Wasmuth, Jan-Christian; Menting, Tanja; Schlabe, Stefan; Rieke, Gereon J; Schwarze-Zander, Carolynne; Rockstroh, Jürgen K; Boesecke, Christoph.
  • van Bremen K; Department of Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany. kathrin.vanbremen@ukbonn.de.
  • Monin M; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany. kathrin.vanbremen@ukbonn.de.
  • Eis-Hübinger AM; Department of Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Marx B; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany.
  • Aldabaggh S; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany.
  • Streeck H; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany.
  • Wasmuth JC; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany.
  • Menting T; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany.
  • Schlabe S; Department of Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Rieke GJ; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany.
  • Schwarze-Zander C; Occupational Health Service, Bonn University Hospital, Bonn, Germany.
  • Rockstroh JK; Department of Medicine I, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Boesecke C; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany.
Infection ; 49(5): 1039-1043, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1274987
Semantic information from SemMedBD (by NLM)
1. Participant LOCATION_OF SARS-CoV-2 IgG
Subject
Participant
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
2. Symptoms CAUSES COVID-19
Subject
Symptoms
Predicate
CAUSES
Object
COVID-19
3. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
4. Communicable Diseases PROCESS_OF Patients
Subject
Communicable Diseases
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Health Personnel
Subject
COVID-19
Predicate
PROCESS_OF
Object
Health Personnel
6. Negative PROCESS_OF Health Personnel
Subject
Negative
Predicate
PROCESS_OF
Object
Health Personnel
7. SARS-CoV-2 IgG NEG_PART_OF Health Personnel
Subject
SARS-CoV-2 IgG
Predicate
NEG_PART_OF
Object
Health Personnel
8. Participant LOCATION_OF SARS-CoV-2 IgG
Subject
Participant
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
9. Symptoms CAUSES COVID-19
Subject
Symptoms
Predicate
CAUSES
Object
COVID-19
10. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
11. Communicable Diseases PROCESS_OF Patients
Subject
Communicable Diseases
Predicate
PROCESS_OF
Object
Patients
12. COVID-19 PROCESS_OF Health Personnel
Subject
COVID-19
Predicate
PROCESS_OF
Object
Health Personnel
13. Negative PROCESS_OF Health Personnel
Subject
Negative
Predicate
PROCESS_OF
Object
Health Personnel
14. SARS-CoV-2 IgG NEG_PART_OF Health Personnel
Subject
SARS-CoV-2 IgG
Predicate
NEG_PART_OF
Object
Health Personnel
ABSTRACT

INTRODUCTION:

The CoSHeP study provides novel data on SARS-CoV-2 seroconversion rates in healthcare professionals (HP) at risk at the University Hospital Bonn, a maximum healthcare provider in a region of 900.000 inhabitants.

METHODS:

Single-center, longitudinal observational study investigating rate of SARS-CoV-2 IgG seroconversion in HP at 2 time-points. SARS-CoV-2 IgG was measured with Roche Elecsys Anti-SARS-CoV-2 assay.

RESULTS:

Overall, 150 HP were included. Median age was 35 (range 19-68). Main operational areas were intensive care unit (53%, n = 80), emergency room (31%, n = 46), and infectious disease department (16%, n = 24). SARS-CoV-2-IgG was detected in 5 participants (3%) at inclusion in May/June 2020, and in another 11 participants at follow-up (December 2020/ January 2021). Of the 16 seropositive participants, 14 had already known their SARS-CoV-2 infection because they had performed a PCR-test previously triggered by symptoms. Trailing chains of infection by self-assessment, 31% (n = 5) of infections were acquired through private contacts, 25% (n = 4) most likely through semi-private contacts during work. 13% (n = 2) were assumed to result through contact with contagious patients, further trailing was unsuccessful in 31% (n = 5). All five participants positive for SARS-CoV-2 IgG at inclusion remained positive with a median of 7 months after infection.

DISCUSSION:

Frontline HP caring for hospitalized patients with COVID-19 are at higher risk of SARS-CoV-2 infections. Noteworthy, based upon identified chains of infection most of the infections were acquired in private environment and semi-private contacts during work. The low rate of infection through infectious patients reveals that professional hygiene standards are effective in preventing SARS-CoV-2 infections in HP. Persisting SARS-CoV-2-IgG might indicate longer lasting immunity supporting prioritization of negative HP for vaccination.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Long Covid / Vaccines Limits: Adult / Humans Language: English Journal: Infection Year: 2021 Document Type: Article Affiliation country: S15010-021-01641-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Long Covid / Vaccines Limits: Adult / Humans Language: English Journal: Infection Year: 2021 Document Type: Article Affiliation country: S15010-021-01641-6