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Long-Term Patient-Centred Follow-up in a Prospective Cohort of Patients with COVID-19.
Righi, Elda; Mirandola, Massimo; Mazzaferri, Fulvia; Razzaboni, Elisa; Zaffagnini, Amina; Erbogasto, Anna; Vecchia, Ilaria Dalla; Auerbach, Nina; Ivaldi, Federico; Mongardi, Maria; Minuz, Pietro; Milella, Michele; Mehrabi, Sara; Olivieri, Oliviero; Girelli, Domenico; Polati, Enrico; Micheletto, Claudio; Tacconelli, Evelina.
  • Righi E; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy. elda.righi@univr.it.
  • Mirandola M; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Mazzaferri F; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Razzaboni E; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Zaffagnini A; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Erbogasto A; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Vecchia ID; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Auerbach N; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Ivaldi F; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Mongardi M; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
  • Minuz P; Section of General Medicine and Hypertension, Medicine Department, University of Verona, Verona, Italy.
  • Milella M; Oncology Division, Medicine Department, University of Verona, Verona, Italy.
  • Mehrabi S; Radiology Division, Diagnostics and Public Health Department, Verona University Hospital, Verona, Italy.
  • Olivieri O; Internal Medicine, Medicine Department, University of Verona, Verona, Italy.
  • Girelli D; Section of Internal Medicine, Medicine Department, University of Verona, Verona, Italy.
  • Polati E; Section of Anaesthesiology, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
  • Micheletto C; Respiratory Unit, Cardiovascular and Thoracic Department, Verona University Hospital, Verona, Italy.
  • Tacconelli E; Infectious Diseases Division, Diagnostics and Public Health Department, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Infect Dis Ther ; 10(3): 1579-1590, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1274997
ABSTRACT

INTRODUCTION:

To better define COVID-19 long-term impact we prospectively analysed patient-centred outcomes, including general health and symptom duration.

METHODS:

Barthel index (BI), St. George's Respiratory Questionnaire adapted to patients with COVID-19 (aSGRQ) and WHO Clinical Progression Scale (CPS) were measured at enrolment and at 6 weeks from the onset of symptoms. Persistence of most frequently reported symptoms was assessed at 6 weeks and, among symptomatic patients, at 12 weeks from the onset of symptoms. Predictors of impaired general health over time were identified using an ordinal multilevel multivariate model.

RESULTS:

A total of 448 patients (55% men, median age 56 years) were enrolled. WHO-CPS showed mild, moderate and severe disease in 48%, 42% and 10% of patients at admission and mild disease in all patients at follow-up, respectively. BI and aSGRQ were normal in 96% and 93% patients before COVID-19 but only in 47% and 16% at COVID-19 diagnosis and in 87% and 65% at 6-week follow-up. Male gender was identified by all three assessments as a predictor of impaired general health (BI, OR 2.14, p < 0.0001; aSGRQ, OR 0.53, p = 0.003; WHO-CPS, OR 1.56, p = 0.01). Other predictors included age, ICU admission and comorbidities (e.g. cardiovascular disease and cancer) for BI, hospital admission for aSGRQ, age and presence of comorbidities for WHO-CPS. At 6- and 12-week follow-up, 39% and 20% of patients, respectively, were still reporting symptoms. Fatigue and breathlessness were the most frequently reported symptoms.

CONCLUSIONS:

Long-term follow-up facilitates the monitoring of health impairment and symptom persistence and can contribute to plan tailored interventions.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Infect Dis Ther Year: 2021 Document Type: Article Affiliation country: S40121-021-00461-3

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Infect Dis Ther Year: 2021 Document Type: Article Affiliation country: S40121-021-00461-3