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Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study.
Garcia-Ruiz, Itziar; Sulleiro, Elena; Serrano, Berta; Fernandez-Buhigas, Irene; Rodriguez-Gomez, Leire; Sanchez-Nieves Fernandez, David; Anton-Pagarolas, Andrés; Esperalba-Esquerra, Juliana; Frick, Marie Antoinette; Camba, Fatima; Navarro-Jimenez, Alexandra; Fernandez-Hidalgo, Nuria; Maiz, Nerea; Carreras, Elena; Suy, Anna.
  • Garcia-Ruiz I; Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall D´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Sulleiro E; Microbiology Department, Hospital Universitari Vall d'Hebron, PROSICS Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Serrano B; Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall D´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Fernandez-Buhigas I; Department of Obstetrics and Gynaecology, University Hospital of Torrejon, Madrid, Spain; School of Medicine, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain.
  • Rodriguez-Gomez L; Biocruces Bizkaia Health Research Institute. Osakidetza, Department of Obstetrics and Gynaecology, Hospital Universitario Cruces, UPV/EHU, Barakaldo, Bizkaia, Spain.
  • Sanchez-Nieves Fernandez D; Department of Obstetrics and Gynaecology, University Hospital Príncipe de Asturias de Alcalá de Henares, Madrid, Spain.
  • Anton-Pagarolas A; Microbiology Department, Hospital Universitari Vall d'Hebron, PROSICS Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Esperalba-Esquerra J; Microbiology Department, Hospital Universitari Vall d'Hebron, PROSICS Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Frick MA; Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d' Hebron, Vall d' Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Camba F; Department of Neonatology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Navarro-Jimenez A; Pathology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Fernandez-Hidalgo N; Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain.
  • Maiz N; Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall D´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: nmaiz@vhebron.net.
  • Carreras E; Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall D´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Suy A; Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall D´Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Clin Microbiol Infect ; 27(10): 1521.e1-1521.e5, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1275224
ABSTRACT

OBJECTIVE:

To evaluate the evidence of mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS:

This is a descriptive, multicentre, observational study in nine tertiary care hospitals throughout Spain. The study population was women with coronavirus disease 2019 during pregnancy. Mother-to-child transmission was defined as positive real-time RT-PCR of SARS-CoV-2 in amniotic fluid, cord blood, placenta or neonatal nasopharyngeal swabs taken immediately after birth.

RESULTS:

We included 43 women with singleton pregnancies and one with a twin pregnancy, as a result we obtained 45 samples of placenta, amniotic fluid and umbilical cord blood. The median gestational age at diagnosis was 34.7 weeks (range 14-41.3 weeks). The median interval between positive RT-PCR and delivery was 21.5 days (range 0-141 days). Fourteen women (31.8%, 95% CI 18.6%-47.6%) were positive at the time of delivery. There was one singleton pregnancy with SARS-CoV-2 RT-PCR positive in the placenta, amniotic fluid and umbilical cord blood (2.2%, 95% CI 0.1%-11.8%). Nasopharyngeal aspiration was performed on 38 neonates at birth, all of which were negative (0%, 95% CI 0%-9.3%). In 11 neonates the nasopharyngeal aspiration was repeated at 24-48 hours, and one returned positive (9.1%, 95% CI 0.2%-41.3%).

CONCLUSIONS:

The presence of SARS-CoV-2 in placenta, amniotic fluid and cord blood shows that mother-to-child transmission is possible but uncommon.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Infectious Disease Transmission, Vertical / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Middle aged / Infant, Newborn / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: J.cmi.2021.06.016

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Infectious Disease Transmission, Vertical / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Middle aged / Infant, Newborn / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: J.cmi.2021.06.016