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Progress and pitfalls of a year of drug repurposing screens against COVID-19.
Sourimant, Julien; Aggarwal, Megha; Plemper, Richard K.
  • Sourimant J; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States. Electronic address: jsourimant@gsu.edu.
  • Aggarwal M; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
  • Plemper RK; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Curr Opin Virol ; 49: 183-193, 2021 08.
Article in English | MEDLINE | ID: covidwho-1275241
ABSTRACT
Near the end of 2019, a new betacoronavirus started to efficiently transmit between humans, resulting in the current COVID-19 pandemic. Unprecedented worldwide efforts were made to identify and repurpose antiviral therapeutics from collections of approved drugs and known bioactive compounds. Typical pitfalls of this approach (promiscuous/cytotoxic compounds leading to false positives), combined with bypassing antiviral drug development parameters due to urgency have resulted in often disappointing outcomes. A flood of publications, press-releases, and media posts, created confusion in the general public and sometime mobilized precious resources for clinical trials with minimal prospect of success. Breakthroughs have been made, not in the laboratory but in the clinic, resulting from the empiric identification of mitigators of clinical signs such as the discovery of improved disease management through immunomodulators. This opinion piece will aim to capture some of the lessons that we believe the COVID-19 pandemic has taught about drug repurposing screens.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Repositioning / COVID-19 Type of study: Observational study / Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Repositioning / COVID-19 Type of study: Observational study / Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article