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Natural killer cells and unconventional T cells in COVID-19.
Björkström, Niklas K; Ponzetta, Andrea.
  • Björkström NK; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. Electronic address: niklas.bjorkstrom@ki.se.
  • Ponzetta A; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Curr Opin Virol ; 49: 176-182, 2021 08.
Article in English | MEDLINE | ID: covidwho-1275242
ABSTRACT
NK cells and diverse populations of unconventional T cells, such as MAIT cells, γδ T cells, invariant NKT cells, and DNTÉ‘ß cells are important early effector lymphocytes. While some of these cells, such as NK cell and MAIT cells, have well-established roles in antiviral defense, the function of other populations remains more elusive. Here, we summarize and discuss current knowledge on NK cell and unconventional T cell responses to SARS-CoV-2 infection. Also covered is the role of these cells in the pathogenesis of severe COVID-19. Understanding the early, both systemic and local (lung), effector lymphocyte response in this novel disease will likely aid ongoing efforts to combat the pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Killer Cells, Natural / T-Lymphocytes / COVID-19 Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Killer Cells, Natural / T-Lymphocytes / COVID-19 Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article