Natural killer cells and unconventional T cells in COVID-19.
Curr Opin Virol
; 49: 176-182, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1275242
ABSTRACT
NK cells and diverse populations of unconventional T cells, such as MAIT cells, γδ T cells, invariant NKT cells, and DNTÉß cells are important early effector lymphocytes. While some of these cells, such as NK cell and MAIT cells, have well-established roles in antiviral defense, the function of other populations remains more elusive. Here, we summarize and discuss current knowledge on NK cell and unconventional T cell responses to SARS-CoV-2 infection. Also covered is the role of these cells in the pathogenesis of severe COVID-19. Understanding the early, both systemic and local (lung), effector lymphocyte response in this novel disease will likely aid ongoing efforts to combat the pandemic.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
T-Lymphocytes
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Curr Opin Virol
Year:
2021
Document Type:
Article
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