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Using cross-species vaccination approaches to counter emerging infectious diseases.
Warimwe, George M; Francis, Michael J; Bowden, Thomas A; Thumbi, Samuel M; Charleston, Bryan.
  • Warimwe GM; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. george.warimwe@ndm.ox.ac.uk.
  • Francis MJ; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. george.warimwe@ndm.ox.ac.uk.
  • Bowden TA; The Pirbright Institute, Woking, UK. george.warimwe@ndm.ox.ac.uk.
  • Thumbi SM; BioVacc Consulting Ltd, Amersham, UK.
  • Charleston B; Wellcome Centre for Human Genetics, Division of Structural Biology, University of Oxford, Oxford, UK.
Nat Rev Immunol ; 21(12): 815-822, 2021 12.
Article in English | MEDLINE | ID: covidwho-1275932
ABSTRACT
Since the initial use of vaccination in the eighteenth century, our understanding of human and animal immunology has greatly advanced and a wide range of vaccine technologies and delivery systems have been developed. The COVID-19 pandemic response leveraged these innovations to enable rapid development of candidate vaccines within weeks of the viral genetic sequence being made available. The development of vaccines to tackle emerging infectious diseases is a priority for the World Health Organization and other global entities. More than 70% of emerging infectious diseases are acquired from animals, with some causing illness and death in both humans and the respective animal host. Yet the study of critical host-pathogen interactions and the underlying immune mechanisms to inform the development of vaccines for their control is traditionally done in medical and veterinary immunology 'silos'. In this Perspective, we highlight a 'One Health vaccinology' approach and discuss some key areas of synergy in human and veterinary vaccinology that could be exploited to accelerate the development of effective vaccines against these shared health threats.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Vaccination / Cross Reactions / Communicable Diseases, Emerging / Viral Zoonoses Type of study: Observational study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Journal: Nat Rev Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41577-021-00567-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Vaccination / Cross Reactions / Communicable Diseases, Emerging / Viral Zoonoses Type of study: Observational study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Journal: Nat Rev Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41577-021-00567-2