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Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study.
Iannetta, Marco; Buccisano, Francesco; Fraboni, Daniela; Malagnino, Vincenzo; Campogiani, Laura; Teti, Elisabetta; Spalliera, Ilaria; Rossi, Benedetta; Di Lorenzo, Andrea; Palmieri, Raffaele; Crea, Angela; Zordan, Marta; Vitale, Pietro; Voso, Maria Teresa; Andreoni, Massimo; Sarmati, Loredana.
  • Iannetta M; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy. marco.iannetta@uniroma2.it.
  • Buccisano F; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy. marco.iannetta@uniroma2.it.
  • Fraboni D; Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
  • Malagnino V; Department of Oncohematology, Policlinico Tor Vergata, Rome, Italy.
  • Campogiani L; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
  • Teti E; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy.
  • Spalliera I; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
  • Rossi B; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy.
  • Di Lorenzo A; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
  • Palmieri R; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy.
  • Crea A; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
  • Zordan M; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy.
  • Vitale P; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
  • Voso MT; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy.
  • Andreoni M; Department of System Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
  • Sarmati L; Infectious Disease Clinic, Policlinico Tor Vergata, Rome, Italy.
Sci Rep ; 11(1): 12762, 2021 06 17.
Article in English | MEDLINE | ID: covidwho-1275947
ABSTRACT
The aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified according to in-hospital mortality (survivors/nonsurvivors) and the maximal oxygen support/ventilation supply required (nonsevere/severe). Demographics, clinical and laboratory data, and peripheral blood lymphocyte subsets were retrospectively analyzed. Overall, 160 patients were retrospectively included in the study. T-lymphocyte subset (total CD3+, CD3+ CD4+, CD3+ CD8+, CD3+ CD4+ CD8+ double positive [DP] and CD3+ CD4- CD8- double negative [DN]) absolute counts were decreased in nonsurvivors and in patients with severe disease compared to survivors and nonsevere patients (p < 0.001). Multivariable logistic regression analysis showed that absolute counts of CD3+ T-lymphocytes < 524 cells/µl, CD3+ CD4+ < 369 cells/µl, and the number of T-lymphocyte subsets below the cutoff (T-lymphocyte subset index [TLSI]) were independent predictors of in-hospital mortality. Baseline T-lymphocyte subset counts and TLSI were also predictive of disease severity (CD3+ < 733 cells/µl; CD3+ CD4+ < 426 cells/µl; CD3+ CD8+ < 262 cells/µl; CD3+ DP < 4.5 cells/µl; CD3+ DN < 18.5 cells/µl). The evaluation of peripheral T-lymphocyte absolute counts in the early stages of COVID-19 might represent a useful tool for identifying patients at increased risk of unfavorable outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-90983-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-90983-0