Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis.
Tissue Barriers
; 9(4): 1929787, 2021 10 02.
Article
in English
| MEDLINE | ID: covidwho-1276097
ABSTRACT
Endothelial barrier dysfunction (EBD) is the hallmark of Acute Respiratory Distress Syndrome (ARDS), a potentially lethal respiratory disorder associated with the COVID-19 - related deaths. Herein, we employed a cecal ligation and puncture (CLP) murine model of sepsis, to evaluate the effects of sepsis-induced EBD in the expression of the never in mitosis A (NIMA)-related kinases (NEKs). Members of that family of kinases regulate the activity and expression of the tumor suppressor P53, previously shown to modulate the actin cytoskeleton remodeling. Our results introduce the induction of NEK2, NEK3, NEK4, NEK7, and NEK9 in a CLP model of sepsis. Hence, we suggest that NEKs are involved in inflammatory processes and are holding the potential to serve as novel therapeutic targets for pathologies related to EBD, including ARDS and sepsis. Further studies will delineate the underlying molecular events and their interrelations with P53.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sepsis
/
NIMA-Related Kinases
/
Lung
Type of study:
Experimental Studies
Limits:
Animals
Language:
English
Journal:
Tissue Barriers
Year:
2021
Document Type:
Article
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