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Does pre-existent physical inactivity have a role in the severity of COVID-19?
Yuan, Qilin; Huang, Hua-Yao; Chen, Xiao-Ling; Chen, Rong-Hua; Zhang, Yixian; Pan, Xiao-Bin; Chen, Jun-Nian; Liu, Nan; Du, Houwei.
  • Yuan Q; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China, and Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.
  • Huang HY; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen XL; Department of Infectious Disease, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen RH; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China, and Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.
  • Zhang Y; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.
  • Pan XB; Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, Fuzhou, China.
  • Chen JN; Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, Fuzhou, China.
  • Liu N; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China, and.
  • Du H; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.
Ther Adv Respir Dis ; 15: 17534666211025221, 2021.
Article in English | MEDLINE | ID: covidwho-1277888
ABSTRACT
BACKGROUND AND

AIMS:

Physical inactivity is considered an important lifestyle factor for overweight and cardiovascular disease. We aimed to investigate the association between pre-existent physical inactivity and the risk of severe coronavirus disease 2019 (COVID-19).

METHODS:

We included 164 (61.8 ± 13.6 years) patients with COVID-19 who were admitted between 15 February and 14 March 2020 in this retrospective study. We evaluated the association between pre-existent physical inactivity and severe COVID-19 using a logistic regression model.

RESULTS:

Of 164 eligible patients with COVID-19, 103 (62.8%) were reported to be physically inactive. Univariable logistic regression analysis showed that physical inactivity was associated with an increased risk of severe COVID-19 [unadjusted odds ratio (OR) 6.53, 95% confidence interval (CI) 1.88-22.62]. In the multivariable regression analysis, physical inactivity remained significantly associated with an increased risk of severe COVID-19 (adjusted OR 4.12, 95% CI 1.12-15.14) after adjustment for age, sex, stroke, and overweight.

CONCLUSION:

Our data showed that pre-existent physical inactivity was associated with an increased risk of experiencing severe COVID-19. Our findings indicate that people should be encouraged to keep physically active to be at a lower risk of experiencing a severe illness when COVID-19 infection seems unpredicted.The reviews of this paper are available via the supplemental material section.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sedentary Behavior / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Ther Adv Respir Dis Journal subject: Pulmonary Disease (Specialty) / Therapeutics Year: 2021 Document Type: Article Affiliation country: 17534666211025221

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sedentary Behavior / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Ther Adv Respir Dis Journal subject: Pulmonary Disease (Specialty) / Therapeutics Year: 2021 Document Type: Article Affiliation country: 17534666211025221