Euglycaemic ketoacidosis in pregnant women with COVID-19: two case reports.
BMC Pregnancy Childbirth
; 21(1): 427, 2021 Jun 16.
Article
in English
| MEDLINE | ID: covidwho-1277922
ABSTRACT
BACKGROUND:
Euglycaemic ketoacidosis (EKA) is an infrequent but serious condition which usually follows a period of starvation, severe vomiting or illness in individuals with or without diabetes. Ketoacidosis is associated with materno-fetal morbidity and mortality necessitating prompt diagnosis and management. Physiological increases in insulin resistance render pregnancy a diabetogenic state with increased susceptibility to ketosis. COVID-19 is associated with worse clinical outcomes in patients with diabetes and is an independent risk factor for ketoacidosis in normoglycaemic individuals. CASE PRESENTATIONS We describe two cases of SARS-CoV-2 positive pregnant women presenting with normoglycaemic metabolic ketoacidosis. Both cases were associated with maternal and fetal compromise, requiring aggressive fluid and insulin resuscitation and early delivery.CONCLUSION:
We discuss possible physiology and propose a management strategy for euglycaemic ketoacidosis in pregnancy.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Starvation
/
COVID-19
/
Ketosis
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
BMC Pregnancy Childbirth
Journal subject:
Obstetrics
Year:
2021
Document Type:
Article
Affiliation country:
S12884-021-03928-w
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