Aging and respiratory viral infection: from acute morbidity to chronic sequelae.
Cell Biosci
; 11(1): 112, 2021 Jun 22.
Article
in English
| MEDLINE | ID: covidwho-1277971
ABSTRACT
The altered immune response in aged hosts play a vital role in contributing to their increased morbidity and mortality during respiratory virus infections. The aged hosts display impaired antiviral immune response as well as increased risk for long-term pulmonary sequelae post virus clearance. However, the underlying cellular and molecular mechanisms driving these alterations of the immune compartment have not been fully elucidated. During the era of COVID-19 pandemic, a better understanding of such aspects is urgently needed to provide insight that will benefit the geriatric patient care in prevention as well as treatment. Here, we review the current knowledge about the unique immune characteristics of aged hosts during homeostasis and respiratory virus infections.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Cell Biosci
Year:
2021
Document Type:
Article
Affiliation country:
S13578-021-00624-2
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