Strategic testing approaches for targeted disease monitoring can be used to inform pandemic decision-making.
PLoS Biol
; 19(6): e3001307, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1278163
ABSTRACT
More than 1.6 million Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) tests were administered daily in the United States at the peak of the epidemic, with a significant focus on individual treatment. Here, we show that objective-driven, strategic sampling designs and analyses can maximize information gain at the population level, which is necessary to increase situational awareness and predict, prepare for, and respond to a pandemic, while also continuing to inform individual treatment. By focusing on specific objectives such as individual treatment or disease prediction and control (e.g., via the collection of population-level statistics to inform lockdown measures or vaccine rollout) and drawing from the literature on capture-recapture methods to deal with nonrandom sampling and testing errors, we illustrate how public health objectives can be achieved even with limited test availability when testing programs are designed a priori to meet those objectives.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pandemics
/
Epidemiological Monitoring
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
PLoS Biol
Journal subject:
Biology
Year:
2021
Document Type:
Article
Affiliation country:
Journal.pbio.3001307
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